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首页> 外文期刊>PLoS One >Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma
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Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma

机译：纤维调节蛋白缺乏会减少结肠癌同基因模型中的胶原结构网络，但不会降低糖胺聚糖含量

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摘要

Tumor barrier function in carcinoma represents a major challenge to treatment and is therefore an attractive target for increasing drug delivery. Variables related to tumor barrier include aberrant blood vessels, high interstitial fluid pressure, and the composition and structure of the extracellular matrix. One of the proteins associated with dense extracellular matrices is fibromodulin, a collagen fibrillogenesis modulator expressed in tumor stroma but scarce in normal loose connective tissues. Here, we investigated the effects of fibromodulin on stroma ECM in a syngeneic murine colon carcinoma model. We show that fibromodulin deficiency decreased collagen fibril thickness but glycosaminoglycan content and composition were unchanged. Furthermore, vascular density, pericyte coverage and macrophage amount were unaffected. Fibromodulin can therefore be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function.
机译：肿瘤中的肿瘤屏障功能代表了治疗的主要挑战，因此是增加药物输送的有吸引力的靶标。与肿瘤屏障有关的变量包括异常血管，高间质液压力以及细胞外基质的组成和结构。与致密的​​细胞外基质有关的蛋白质之一是纤维调节蛋白，纤维蛋白调节蛋白在肿瘤基质中表达，但在正常的疏松结缔组织中却很少。在这里，我们调查了同基因鼠结肠癌模型中纤维调节蛋白对基质ECM的影响。我们表明，纤维调节蛋白缺乏症降低了胶原蛋白原纤维的厚度，但糖胺聚糖的含量和组成均未改变。此外，血管密度，周细胞覆盖率和巨噬细胞数量不受影响。因此，纤维调节蛋白可以是肿瘤基质中致密胶原基质组装的独特效应物，并且在不影响其他主要基质组分或细胞组成的情况下，可以充当肿瘤屏障功能的主要药剂。

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