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首页> 外文期刊>PLOS Neglected Tropical Diseases >Novel Insights into the Genetic Diversity of Balantidium and Balantidium -like Cyst-forming Ciliates
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Novel Insights into the Genetic Diversity of Balantidium and Balantidium -like Cyst-forming Ciliates

机译：Bal和and样囊肿形成纤毛的遗传多样性的新见解。

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Balantidiasis is considered a neglected zoonotic disease with pigs serving as reservoir hosts. However, Balantidium coli has been recorded in many other mammalian species, including primates. Here, we evaluated the genetic diversity of B. coli in non-human primates using two gene markers (SSrDNA and ITS1-5.8SDNA-ITS2). We analyzed 49 isolates of ciliates from fecal samples originating from 11 species of captive and wild primates, domestic pigs and wild boar. The phylogenetic trees were computed using Bayesian inference and Maximum likelihood. Balantidium entozoon from edible frog and Buxtonella sulcata from cattle were included in the analyses as the closest relatives of B. coli, as well as reference sequences of vestibuliferids. The SSrDNA tree showed the same phylogenetic diversification of B. coli at genus level as the tree constructed based on the ITS region. Based on the polymorphism of SSrDNA sequences, the type species of the genus, namely B. entozoon, appeared to be phylogenetically distinct from B. coli. Thus, we propose a new genus Neobalantidium for the homeothermic clade. Moreover, several isolates from both captive and wild primates (excluding great apes) clustered with B. sulcata with high support, suggesting the existence of a new species within this genus. The cysts of Buxtonella and Neobalantidium are morphologically indistinguishable and the presence of Buxtonella-like ciliates in primates opens the question about possible occurrence of these pathogens in humans.
机译：anti虫病被认为是一种被忽视的人畜共患病，以猪为宿主。但是，已在许多其他哺乳动物物种（包括灵长类动物）中记录到了Balantidium coli。在这里，我们使用两个基因标记（SSrDNA和ITS1-5.8SDNA-ITS2）评估了非人类灵长类动物中B. coli的遗传多样性。我们分析了来自11种圈养和野生灵长类动物，家猪和野猪的粪便样本中的纤毛虫49株。使用贝叶斯推断和最大似然计算系统发育树。分析中包括来自可食用青蛙的肠虫和来自牛的苏克氏杆菌，作为大肠杆菌的最亲近亲属以及前卫动物的参考序列。 SSrDNA树在属水平上显示出与基于ITS区域构建的树相同的细菌进化多样性。基于SSrDNA序列的多态性，该属的类型物种，即肠杆菌（B. entozoon），在系统发育上似乎不同于大肠杆菌。因此，我们提出了一种新的等温进化枝新balantium。此外，从圈养和野生灵长类动物（不包括大猿类）中分离出的几种分离物在高支持度下与苏卡特芽孢杆菌聚集在一起，这表明该属中存在一个新物种。 Buxtonella和Neobalantidium的囊肿在形态上是无法区分的，灵长类动物中存在Buxtonella样纤毛的现象为人们提出了这些病原体可能发生的问题。

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