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Phylogeography of Recently Emerged DENV-2 in Southern Viet Nam

机译：越南南部最近出现的DENV-2的系统志

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Revealing the dispersal of dengue viruses (DENV) in time and space is central to understanding their epidemiology. However, the processes that shape DENV transmission patterns at the scale of local populations are not well understood, particularly the impact of such factors as human population movement and urbanization. Herein, we investigated trends in the spatial dynamics of DENV-2 transmission in the highly endemic setting of southern Viet Nam. Through a phylogeographic analysis of 168 full-length DENV-2 genome sequences obtained from hospitalized dengue cases from 10 provinces in southern Viet Nam, we reveal substantial genetic diversity in both urban and rural areas, with multiple lineages identified in individual provinces within a single season, and indicative of frequent viral migration among communities. Focusing on the recently introduced Asian I genotype, we observed particularly high rates of viral exchange between adjacent geographic areas, and between Ho Chi Minh City, the primary urban center of this region, and populations across southern Viet Nam. Within Ho Chi Minh City, patterns of DENV movement appear consistent with a gravity model of virus dispersal, with viruses traveling across a gradient of population density. Overall, our analysis suggests that Ho Chi Minh City may act as a source population for the dispersal of DENV across southern Viet Nam, and provides further evidence that urban areas of Southeast Asia play a primary role in DENV transmission. However, these data also indicate that more rural areas are also capable of maintaining virus populations and hence fueling DENV evolution over multiple seasons.
机译：揭示登革热病毒在时间和空间上的传播是了解其流行病学的关键。但是，人们对形成DENV传播模式的当地人口规模的过程知之甚少，尤其是诸如人口流动和城市化等因素的影响。在这里，我们调查了越南南部高度流行的环境中DENV-2传播的空间动力学趋势。通过对从越南南部10个省的住院登革热病例获得的168个全长DENV-2基因组序列进行系统学分析，我们揭示了城市和农村地区的大量遗传多样性，并在单个季节内确定了各个省份的多个谱系，并且表明社区之间病毒的频繁迁移。着眼于最近引进的亚洲I型基因型，我们观察到相邻地理区域之间，该地区主要城市中心胡志明市与越南南部人口之间的病毒交换率特别高。在胡志明市内，DENV运动的模式似乎与病毒扩散的引力模型一致，病毒在人口密度梯度上传播。总体而言，我们的分析表明，胡志明市可能是DENV在越南南部扩散的来源人口，并进一步证明了东南亚城市地区在DENV传播中起主要作用。但是，这些数据还表明，更多的农村地区也能够维持病毒种群，因此推动了多个季节的DENV进化。

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