Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines

Nicolas Dauby; Cristina Alonso-Vega; Eduardo Suarez; Amilcar Flores; Emmanuel Hermann; Marisol Córdova; Tatiana Tellez; Faustino Torrico; Carine Truyens; Yves Carlier

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Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines

机译：克鲁氏锥虫和先天性南美锥虫病的母亲感染导致婴儿对疫苗的免疫反应呈1型极化趋势。

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Background We previously showed that newborns congenitally infected with Trypanosoma cruzi (M+B+) display a strong type 1 parasite-specific T cell immune response, whereas uninfected newborns from T. cruzi-infected mothers (M+B?) are prone to produce higher levels of proinflammatory cytokines than control neonates (M?B?). The purpose of the present study was to determine if such fetaleonatal immunological environments could alter the response to standard vaccines administered in early life.

机译：背景我们以前曾证明，先天感染克鲁斯锥虫（M + B +）的新生儿表现出强烈的1型寄生虫特异性T细胞免疫反应，而未感染克鲁斯锥虫的母亲（M + B？）则容易产生更高的出生率。炎性细胞因子水平高于对照组（M？B？）。本研究的目的是确定这种胎儿/新生儿的免疫学环境是否可以改变对生命早期施用的标准疫苗的反应。

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《PLOS Neglected Tropical Diseases》 |2009年第12期|共9页
作者
Nicolas Dauby; Cristina Alonso-Vega; Eduardo Suarez; Amilcar Flores; Emmanuel Hermann; Marisol Córdova; Tatiana Tellez; Faustino Torrico; Carine Truyens; Yves Carlier;
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1. Are maternal re-infections with Trypanosoma cruzi associated with higher morbidity and mortality of congenital Chagas disease? [J] . Torrico F, Vega CA, Suarez E, Tropical Medicine and International Health: TM and IH . 2006,第5期

机译：克氏锥虫的母亲再感染是否与先天性南美锥虫病的较高发病率和死亡率相关？
2. Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease [J] . Rios Lizette, Emanuel Campos E., Menon Ramkumar, Biochimica et biophysica acta. Molecular basis of disease: BBA . 2020,第3期

机译：曲盼克鲁齐母胎传播的流行病学及发病机制及对先天性芝麻疾病的疫苗发育案例
3. Cell mediated immunity in Chagas' disease: Trypanosoma cruzi antigens induce suppression of the in vitro proliferative response of mononuclear cells [J] . Luis Brice?o, Maria Ignacia Hernandez, Walter Mosca Memórias do Instituto Oswaldo Cruz . 1991,第2期

机译：恰加斯氏病中细胞介导的免疫力：克鲁斯锥虫抗原诱导抑制单核细胞的体外增殖反应
4. A Multiagent-based Simulation of the Infection of the Macrophage by Trypanosoma Cruzi in the Acute Phase of Chagas' Disease: Influence of the Initial Inoculum and Protozoan Escape Factor [C] . Willian Cordeiro Farago, Alcione de Paiva Oliveira, Rodrigo Siqueira-Batista, International Conference on Enterprise Information Systems . 2016

机译：基于多噬细胞急性疾病急性期巨噬细胞感染的多元模拟：初始接种物和原生动物逃生因子的影响
5. The regulation of infection-induced cardiac autoimmunity and natural dissemination of Trypanosoma cruzi in experimental Chagas heart disease [D] . Hyland, Kenneth V. 2008

机译：实验性南美锥虫性心脏病感染引起的心脏自身免疫性和克鲁氏锥虫自然传播的调节
6. Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines [O] . Nicolas Dauby, Cristina Alonso-Vega, Eduardo Suarez, 2009

机译：克鲁氏锥虫和先天性南美锥虫病的母亲感染导致婴儿对疫苗的免疫反应呈1型极化趋势。
7. Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines [O] . Dauby, Nicolas, Alonso-Vega, Cristina, Suarez, Eduardo, 2009

机译：克鲁氏锥虫和先天性南美锥虫病的母亲感染导致婴儿对疫苗的免疫反应呈1型极化趋势。
8. Experimental Chagas' Disease (Trypanosoma cruzi) in the Brazilian Squirrel Monkey (Saimiri sciureus): Hematology, Cardiology, Cellular and Humoral Immune Responses. (Reannouncement with New Availability Information). [R] . Pung, O. J., Hulsebos, L. H., Kuhn, R. E. 1988

机译：实验性恰加斯病（克氏锥虫）在巴西松鼠猴（saimiri sciureus）：血液学，心脏病学，细胞和体液免疫反应。（重新公布新的可用性信息）。

Maternal Infection with Trypanosoma cruzi and Congenital Chagas Disease Induce a Trend to a Type 1 Polarization of Infant Immune Responses to Vaccines

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