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首页> 外文期刊>PLoS One >Circadian pattern of short-term variability of the QT-interval in primary prevention ICD patients - EU-CERT-ICD methodological pilot study
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Circadian pattern of short-term variability of the QT-interval in primary prevention ICD patients - EU-CERT-ICD methodological pilot study

机译：一级预防性ICD患者QT间隔的短期变化的昼夜节律模式-EU-CERT-ICD方法学试点研究

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Objective Short-term variability of the QT-interval (STV-QT) was shown to be associated with an increased risk of ventricular arrhythmias. We aimed at investigating (a) whether STV-QT exhibits circadian pattern, and (b) whether such pattern differs between patients with high and low arrhythmia risk. Methods As part of the ongoing EU-CERT-ICD study, 24h high resolution digital ambulatory 12-lead Holter recordings are collected prior to ICD implantation for primary prophylactic indication. Presently available patients were categorized based on their arrhythmia score (AS), a custom-made weighted score of the number of arrhythmic events on the recording. STV-QT was calculated every hour in 30 patients of which 15 and 15 patients had a high and a low AS, respectively. Results The overall dynamicity of STV-QT showed high intra- and inter-individual variability with different circadian patterns associated with low and high AS. High AS patients showed a prominent peak both at 08:00 and 18:00. At these times, STV-QT was significantly higher in the high AS patients compared to the low AS patients (1.22ms±0.55ms vs 0.60ms±0.24ms at 08:00 and 1.12ms±0.39ms vs 0.64ms±0.29ms at 18:00, both p 0.01). Conclusion In patients with high AS, STV-QT peaks in the early morning and late afternoon. This potentially reflects increased arrhythmia risk at these times. Prospective STV-QT determination at these times might thus be more sensitive to identify patients at high risk of ventricular arrhythmias.
机译：目的显示QT间隔的短期变异性（STV-QT）与室性心律不齐的风险增加相关。我们旨在调查（a）STV-QT是否表现出昼夜节律模式，以及（b）在具有高和低心律失常风险的患者之间这种模式是否有所不同。方法作为正在进行的EU-CERT-ICD研究的一部分，在植入ICD之前收集24h高分辨率数字式动态12导动态心电记录，以进行主要的预防指征。根据他们的心律不齐评分（AS）对心律失常事件数量进行定制的加权评分，对当前可用的患者进行分类。每小时计算30例患者的STV-QT，其中15例和15例AS分别为高和低。结果STV-QT的整体动态表现出较高的个体内和个体间变异性，不同的昼夜节律与低和高AS相关。高AS患者在08:00和18:00均出现显着高峰。在这些时候，高AS患者的STV-QT显着高于低AS患者（08:00时为1.22ms±0.55ms vs 0.60ms±0.24ms，而18:00时为1.12ms±0.39ms vs 0.64ms±0.29ms 18:00，两者均p <0.01）。结论高AS患者中，STV-QT在清晨和午后达到高峰。这可能反映出在这些时候心律失常风险增加。因此，在这些时候对STV-QT进行前瞻性测定可能对识别出室性心律不齐高风险的患者更为敏感。

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