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首页> 外文期刊>PLOS Neglected Tropical Diseases >Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome
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Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome

机译：鉴定散布在圆盘虫蛋白质组上的三个具有非典型同种型的免疫优势基序

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摘要

Understanding the immune response upon infection with the filarial nematode Onchocerca volvulus and the mechanisms that evolved in this parasite to evade immune mediated elimination is essential to expand the toolbox available for diagnostics, therapeutics and vaccines development. Using high-density peptide microarrays we scanned the proteome-wide linear epitope repertoire in Cameroonian onchocerciasis patients and healthy controls from Southern Africa which led to the identification of 249 immunodominant antigenic peptides. Motif analysis learned that 3 immunodominant motifs, encompassing 3 linear epitopes, are present in 70, 43, and 31 of these peptides, respectively and appear to be scattered over the entire proteome in seemingly non-related proteins. These linear epitopes are shown to have an atypical isotype profile dominated by IgG1, IgG3, IgE and IgM, in contrast to the commonly observed IgG4 response in chronic active helminth infections. The identification of these linear epitope motifs may lead to novel diagnostic development but further evaluation of cross-reactivity against common co-infecting human nematode infections will be needed.
机译：了解丝虫线虫感染后的免疫反应以及在此寄生虫中逃逸以逃避免疫介导消除的机制，对于扩大可用于诊断，治疗和疫苗开发的工具箱至关重要。使用高密度肽微阵列，我们扫描了喀麦隆盘尾丝虫病患者和南部非洲健康对照的蛋白质组范围的线性表位库，从而鉴定了249个免疫优势抗原肽。 Motif分析发现，这些肽的70、43和31中分别存在3个免疫优势基序，其中包括3个线性表位，似乎散布在看似无关的整个蛋白质组中。这些线性表位显示具有由IgG1，IgG3，IgE和IgM支配的非典型同型谱，这与在慢性活动性蠕虫感染中通常观察到的IgG4反应相反。这些线性表位基序的鉴定可能会导致新的诊断发展，但将需要进一步评估对常见的共同感染人类线虫感染的交叉反应性。

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