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首页> 外文期刊>PLoS One >Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents
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Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents

机译：香豆素衍生物作为抗利什曼肽的生物活性

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摘要

Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p0.05) suggesting that compound 2 may possess anti-leishmanial properties.
机译：皮肤利什曼病每年影响近0.7至130万人。由于缺乏适当的药物和耐药性的日益严重的问题，这种疾病的治疗很困难。天然化合物（如香豆素）除目前的治疗方式外，还可以作为补充治疗剂。在这项研究中，我们对香豆素衍生物进行了计算机筛选，并在体外和体内研究了它们的抗利什曼特性。其中一种化合物（化合物2）表现出杀菌作用，为进一步研究其性能，开发了该化合物的纳米脂质体制剂。与未处理的小鼠相比，用化合物2处理BALB / c小鼠的皮肤病变显示出明显减小的病变大小（p <0.05），表明化合物2可能具有抗利什曼特性。

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