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首页> 外文期刊>Polish Archives of Internal Medicine >The impact of high?density lipoprotein on oxidant–antioxidant balance in healthy elderly people
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The impact of high?density lipoprotein on oxidant–antioxidant balance in healthy elderly people

机译：高密度脂蛋白对健康老年人氧化-抗氧化平衡的影响

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INTRODUCTION There is an inverse relationship between high?density lipoprotein cholesterol (HDL-C) levels and the risk of atherosclerosis. OBJECTIVES The aim of the present study was to assess the oxidant–antioxidant balance in elderly people with different concentrations of HDL-C. PATIENTS AND METHODS A total of 541 people aged 60 years or older were examined, of whom 90 individuals with no acute or severe chronic disorders had their waist circumference, body mass index, percentage of body fat, and blood pressure measured. Fasting and 120?minute glycemia was determined in an oral glucose tolerance test, following which 15 patients with type 2 diabetes were excluded. Fasting plasma levels of lipids, total antioxidant status, and thiobarbituric acid-reacting substances (TBARS), as well ast the activity of erythrocyte superoxide dismutase 1 (SOD?1)?were assessed. Based on HDL-C levels, participants were divided into the high HDL?C group (≥40.0 mg/dl and ≥50.0 mg/dl for men and women, respectively; n = 50) and the low HDL?C group (<40.0 mg/dl and <50.0 mg/dl for men and women, respectively; n = 25). RESULTS The groups did not differ in terms of age, blood pressure, body mass index, percentage of body fat, and glucose concentration. The high HDL?C group had lower waist circumference (P <0.02) and lower triglyceride concentrations (P <0.00001). Increased TBARS levels (P <0.0005) was observed in the low HDL?C group. There were no differences in SOD?1 activity and total antioxidant status between the groups. CONCLUSIONS HDL-C levels, which are known to reflect the antiatherogenic activity of HDL, including antioxidant properties, may indicate increasing oxidative stress in healthy elderly individuals.
机译：引言高密度脂蛋白胆固醇（HDL-C）水平与动脉粥样硬化风险之间存在反比关系。目的本研究的目的是评估具有不同浓度HDL-C的老年人中的氧化剂-抗氧化剂平衡。患者和方法共检查了541位60岁或60岁以上的人，其中90位无急性或严重慢性疾病的人的腰围，体重指数，体脂百分比和血压均已测量。在口服葡萄糖耐量试验中确定空腹和120分钟血糖，随后排除15例2型糖尿病患者。评估空腹血浆脂质水平，总抗氧化剂状态和硫代巴比妥酸反应物质（TBARS）以及红细胞超氧化物歧化酶1（SOD？1）的活性。根据HDL-C水平，将参与者分为高HDL？C组（男性和女性分别≥40.0 mg / dl和≥50.0mg / dl; n = 50）和低HDL？C组（<40.0男女分别为mg / dl和<50.0 mg / dl; n = 25）。结果各组在年龄，血压，体重指数，体脂百分比和葡萄糖浓度方面无差异。高HDL？C组的腰围较低（P <0.02），甘油三酸酯浓度较低（P <0.00001）。低HDL？C组的TBARS水平升高（P <0.0005）。两组之间的SOD？1活性和总抗氧化剂状态没有差异。结论HDL-C水平已知反映HDL的抗动脉粥样硬化活性，包括抗氧化特性，可能表明健康的老年人个体中氧化应激增加。

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