Presence of anticardiolipin antibodies in cryoglobulins isolated from sera of hepatitis C virus infected patients

JoannaJab?ońska; JakubZ?bek; JoannaKoz?owska; IwonaKrzewska

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Presence of anticardiolipin antibodies in cryoglobulins isolated from sera of hepatitis C virus infected patients

机译：丙型肝炎病毒感染患者血清中分离出的冷球蛋白中抗心磷脂抗体的存在

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Introduction. Most extrahepatic manifestations of the hepatitis C virus (HCV) infection are connected with influence of virus on the host’s immune system. An important part of immunologic disturbances in chronic infections is the presence of circulating immune complexes. Standard serologic methods are not applicable in analysis of complexes composition. Objectives. Detection of anticardiolipin antibodies (ACA) in cryoglobulins of patients with the HCV infection before and after dissociation of immune complexes. Patients and methods. Sera and croglobulins of 27 patients (19 female, 8 male) with chronic hepatitis C and with cryoglobulinemia were tested. Results. ACA were searched in serum and cryoprecipitate of 27 HCV infected patients with cryoglobulinemia – before and after dissociation of immune complexes. The presence of ACA was not confirmed in sera, but in 59% of cases they were detected in dissociated complexes from cryoprecipitate. The correlation between the presence of anti?HCV antibodies and ACA in cryoprecipitate before dissociation of immune complexes was 0.47 (p

机译：介绍。丙型肝炎病毒（HCV）感染的大多数肝外表现与病毒对宿主免疫系统的影响有关。慢性感染中免疫功能紊乱的重要部分是循环免疫复合物的存在。标准血清学方法不适用于复合物组成的分析。目标。免疫复合物解离前后，HCV感染患者的冷球蛋白中抗心磷脂抗体（ACA）的检测。患者和方法。测试了27例慢性丙型肝炎和冷球蛋白血症患者的血清和球蛋白（19例女性，8例男性）。结果。在解离免疫复合物之前和之后，对27名HCV感染的丙型肝炎病毒感染患者的血清和冷沉淀物中的ACA进行了搜索。血清中未确认ACA的存在，但在59％的病例中，它们是在冷沉淀分离的复合物中检测到的。免疫复合物解离前，冷沉淀物中抗？HCV抗体的存在与ACA之间的相关性为0.47（p

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《Polish Archives of Internal Medicine》 |2008年第1期|共5页
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JoannaJab?ońska; JakubZ?bek; JoannaKoz?owska; IwonaKrzewska;
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机译：在具有单独的抗乙型肝炎核心抗体的HIV /丙型肝炎病毒共感染患者中，聚乙二醇干扰素-利巴韦林治疗期间乙型肝炎病毒复制的重新激活。
2. Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran [J] . Khorvash Farzin, Javadi Abbasali, Tayeri Katayoun, Journal of research in medical sciences : . 2014,第Suppla期

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机译：伊朗伊斯法罕分离的乙型肝炎核心抗体的人免疫缺陷病毒感染患者中的乙型肝炎病毒感染
4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系
5. The pathogenesis of human immunodeficiency virus in a cohort of patients co-infected with hepatitis C virus (Immune deficiency). [D] . Bowker, Samantha L. 2001

机译：在丙型肝炎病毒（免疫缺陷）合并感染的一组患者中，人类免疫缺陷病毒的发病机理。
6. Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans. [O] . M L Meyers, L V Trepo, N Nath, 1986

机译：乙型肝炎病毒多肽X：在大肠埃希菌中的表达以及在乙型肝炎病毒感染者的血清中鉴定特异性抗体。
7. Hepatitis B virus DNA in sera of blood donors and of patients infected with hepatitis C virus and human immunodeficiency virus [O] . Goncales, FL, Pereira, JSF, da Silva, C, 2015

机译：献血者和感染丙型肝炎病毒和人类免疫缺陷病毒的患者血清中的乙肝病毒DNA
8. Inconclusive Hepatitis C Virus Antibody Results in African Sera. (Reannouncementwith New Availability Information) [R] . Hyams, K. C., Okoth, F. A., Tukei, P. M., 1993

机译：非洲血清中不确定的丙型肝炎病毒抗体结果。（重新公布新的可用性信息）

Presence of anticardiolipin antibodies in cryoglobulins isolated from sera of hepatitis C virus infected patients

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