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首页> 外文期刊>Polish Archives of Internal Medicine >Effects of megestrol acetate in patients with cancer anorexia?cachexia syndrome – a systematic review and meta?analysis
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Effects of megestrol acetate in patients with cancer anorexia?cachexia syndrome – a systematic review and meta?analysis

机译：醋酸孕甾醇对癌症厌食症，恶病质综合征患者的疗效-系统评价和荟萃分析

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Introduction. Anorexia?cachexia syndrome (ACS) often occurs in patients with advanced cancer. Objectives. To review the effect of megestrol acetate (MA) in patients with ACS. Patients and methods. To identify eligible studies, systematic review by Lopez et al. (2004) was used, electronic databases (MEDLINE, EMBASE and CENTRAL) were searched and reference lists of included studies were reviewed. The studies were included in the review if they were randomized, enrolled patients with non?hormone?sensitive cancer and ACS and assessed the effects of MA compared with placebo, other drugs or different doses of MA. Results. The study population is characterized by high mortality and progressive weight loss irrespective of the treatment. Compared to placebo, the effect of MA on survival is similar, but MA increases appetite (number needed to treat [NNT]: 3) and leads to weight gain (NNT: 8) in more patients. The data on other aspects of the quality of life are limited. The comparison of MA and glucocorticosteroids showed no statistical difference in their effect on appetite and weight. Conclusions. Compared to placebo, MA reduces the symptoms of ACS, with no effect on survival. The beneficial effect of MA on the overall quality of life has not been confirmed. In identified studies the effect of MA and glucocorticosteroids on anorexia and cachexia is similar. The estimation of the treatment utility in ACS depends on the weight attributed to discomfort caused by symptoms, adverse effects of the drugs and the treatment cost. Because of the low quality of the included studies a new randomized controlled trial is needed for valid assessment of the effects of MA.
机译：介绍。患有晚期癌症的患者经常会发生厌食－恶病质综合征（ACS）。目标。回顾醋酸孕孕酮（MA）在ACS患者中的作用。患者和方法。为了确定合格的研究，洛佩兹等人的系统评价。 （2004）被使用，电子数据库（MEDLINE，EMBASE和CENTRAL）被搜寻并且包括研究的参考名单被回顾。如果研究是随机入组的非激素敏感性癌症和ACS患者，并且与安慰剂，其他药物或不同剂量的MA相比，评估了MA的效果，则该研究包括在评价中。结果。与治疗无关，研究人群的特点是死亡率高和进行性减肥。与安慰剂相比，MA对生存的影响相似，但是MA增加食欲（治疗[NNT]所需的数字：3），并导致更多患者体重增加（NNT：8）。生活质量其他方面的数据有限。 MA和糖皮质激素的比较显示，它们对食欲和体重的影响无统计学差异。结论。与安慰剂相比，MA减轻了ACS的症状，对生存没有影响。 MA对整体生活质量的有益作用尚未得到证实。在确定的研究中，MA和糖皮质激素对厌食和恶病质的作用相似。 ACS中治疗效用的估计取决于因症状，药物的不良作用和治疗费用而引起的不适感。由于纳入研究的质量低下，因此需要一项新的随机对照试验来有效评估MA的疗效。

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