...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polish Archives of Internal Medicine >Glucose intolerance, insulin resistance and metabolic syndrome in patients with stable angina pectoris. Obesity predicts coronary atherosclerosis and dysglycemia
【24h】

Glucose intolerance, insulin resistance and metabolic syndrome in patients with stable angina pectoris. Obesity predicts coronary atherosclerosis and dysglycemia

机译：稳定型心绞痛患者的葡萄糖耐受不良，胰岛素抵抗和代谢综合征。肥胖预示着冠状动脉粥样硬化和血糖异常

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction. Disturbances of glucose regulation and other metabolic disorders, as part of metabolic syndrome, are important risk factors for atherosclerosis. Abnormal glucose metabolism is commonly observed in patients with acute coronary syndrome. However, there is no consistent evidence for subjects with stable angina. Objectives. To investigate the prevalence of glucose metabolism in patients with stable coronary artery disease (CAD) documented angiographically and to assess correlations of metabolic profile and extent of atherosclerotic lesions. Patients and methods. 100 consecutive non-diabetic patients with stable CAD referred to coronary angiography were studied. Total cholesterol and its fractions, triglycerides, uric acid and fasting insulin levels were determined. Oral glucose tolerance test (OGTT) and then coronary angiography were performed. All patients were divided into groups according to glucometabolic and coronary status and insulin resistance. The sum of all lesions in coronary vessels was calculated for each patient (CAD score). Results. After OGTT, 44% of patients presented disturbed glucose metabolism: 9% of patients had newly diagnosed diabetes and 35% patients were in the prediabetic state. There was no correlation between glycemic status and insulin resistance, and severity of coronary heart disease. Obesity, reflected by ?body mass index, waist circumference and waist-to-hip ratio, was a major metabolic disorder and independent predictor of the extent of coronary atherosclerosis and glucose intolerance. Conclusions. Abnormal glucose regulation is very common in patients with stable CAD. Only obesity was the independent predictor of coronary atherosclerosis and dysglycemia. Other metabolic risk factors are target for prevention and treatment.
机译：介绍。作为代谢综合征的一部分，葡萄糖调节紊乱和其他代谢紊乱是动脉粥样硬化的重要危险因素。通常在急性冠状动脉综合征患者中观察到葡萄糖代谢异常。但是，没有稳定的心绞痛患者的一致证据。目标。调查血管造影记录的稳定冠状动脉疾病（CAD）患者的葡萄糖代谢发生率，并评估代谢谱与动脉粥样硬化病变程度的相关性。患者和方法。研究了100例连续的非糖尿病稳定CAD患者，并进行了冠状动脉造影。测定总胆固醇及其分数，甘油三酸酯，尿酸和空腹胰岛素水平。进行口服葡萄糖耐量试验（OGTT），然后进行冠状动脉造影。根据糖代谢和冠状动脉状态以及胰岛素抵抗将所有患者分为几组。计算每位患者的冠状动脉所有病变的总和（CAD评分）。结果。 OGTT后，44％的患者出现葡萄糖代谢紊乱：9％的患者新诊断为糖尿病，35％的患者处于糖尿病前期状态。血糖状态和胰岛素抵抗与冠心病严重程度之间没有相关性。肥胖由体重指数，腰围和腰臀比所反映，是一种主要的代谢紊乱，并且是冠状动脉粥样硬化和葡萄糖耐受不良程度的独立预测因子。结论。 CAD稳定的患者中葡萄糖调节异常非常普遍。只有肥胖是冠状动脉粥样硬化和血糖异常的独立预测因子。其他代谢风险因素是预防和治疗的目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号