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首页> 外文期刊>Revista Brasileira de Cirurgia Plastica >Tratamento de queimadura de segundo grau superficial em face e pesco?o com heparina tópica: estudo comparativo, prospectivo e randomizado
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Tratamento de queimadura de segundo grau superficial em face e pesco?o com heparina tópica: estudo comparativo, prospectivo e randomizado

机译：局部肝素治疗面部和颈部浅表性二度烧伤：一项比较，前瞻性和随机研究

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BACKGROUND: New treatment options for thermal injuries are very desirable, especially if they reduce healing time and pain without increase of infection rates. Recent studies suggest that heparin topical use can achieve those goals. This study has the objective to evaluate healing time, pain and infection rate comparing topical use of heparin and collagenase in the treatment of superficial second degree burns of face and neck. METHODS: Twenty patients were randomized into 2 groups: group treated with topical heparin and group treated with collagenase (control group). The exclusion criteria were: history of bleeding, blood discrasia, allergies to the product, active peptic ulcer and burns with more than 24 hours. Mann-Whitney test was applied to evaluate the results. The pain was measured by the use of opioid analgesics. RESULTS: The heparin was not effective in decrease of healing time nor the use of opioids, and the infection rate didn't present significant difference between the groups. CONCLUSIONS: The heparin can be used safely in treatment of superficial second degree burn of face and neck, but its beneficial effects need to be proven.
机译：背景：热损伤的新治疗方法非常理想，特别是如果它们减少了治愈时间和痛苦而又不增加感染率的话。最近的研究表明，局部使用肝素可以达到这些目标。这项研究的目的是评估局部使用肝素和胶原酶治疗面部和颈部浅度二度烧伤的愈合时间，疼痛和感染率。方法：20例患者随机分为两组：局部肝素治疗组和胶原酶治疗组（对照组）。排除标准为：出血史，血液斑点，对该产品过敏，活动性消化性溃疡和超过24小时的烧伤。进行Mann-Whitney检验以评估结果。通过使用阿片类镇痛药测量疼痛。结果：肝素在缩短愈合时间和使用阿片类药物方面均无效，并且感染率在两组之间没有显着差异。结论：肝素可以安全地用于面部和颈部浅度二度烧伤，但其有益作用有待证明。

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