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首页> 外文期刊>Psoriasis: Targets and Therapy >Optimal management of nail disease in patients with psoriasis
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Optimal management of nail disease in patients with psoriasis

机译：银屑病患者指甲疾病的优化管理

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Abstract: Psoriasis is a common skin disease, with nail involvement in approximately 80% of patients. Nail psoriasis is often associated with psoriatic arthropathy. Involvement of the nails does not always have relationship with the type, gravity, extension, or duration of skin psoriasis. Nail psoriasis can occur at any age and all parts of the nails and the surrounding structures can be affected. Two clinical patterns of nail manifestations have been seen due to psoriasis: nail matrix involvement or nail bed involvement. In the first case, irregular and deep pitting, red spots of the lunula, crumbling, and leukonychia are seen; in the second case, salmon patches, onycholysis with erythematous border, subungual hyperkeratosis, and splinter hemorrhages are observed. These clinical features are more visible in fingernails than in toenails, where nail abnormalities are not diagnostic and are usually clinically indistinguishable from other conditions, especially onychomycosis. Nail psoriasis causes, above all, psychosocial and aesthetic problems, but many patients often complain about functional damage. Diagnosis of nail psoriasis is clinical and histopathology is necessary only in selected cases. Nail psoriasis has an unpredictable course but, in most cases, the disease is chronic and complete remissions are uncommon. Sun exposure does not usually improve and may even worsen nail psoriasis. There are no curative treatments. Treatment of nail psoriasis includes different types of medications, from topical therapy to systemic therapy, according to the severity and extension of the disease. Moreover, we should not underestimate the use of biological agents and new therapy with lasers or iontophoresis. This review offers an investigation of the different treatment options for nail psoriasis and the optimal management of nail disease in patients with psoriasis.
机译：摘要：银屑病是一种常见的皮肤疾病，约80％的患者指甲受累。指甲牛皮癣通常与牛皮癣性关节炎有关。指甲受累并不总是与皮肤牛皮癣的类型，重力，延伸或持续时间有关。指甲牛皮癣可以在任何年龄发生，指甲的所有部位和周围结构都会受到影响。由于牛皮癣，已经观察到两种指甲表现的临床模式：指甲基质受累或指甲床受累。在第一种情况下，观察到不规则和深点蚀，月经肉的红色斑点，碎裂和白喉。在第二种情况下，观察到鲑鱼斑块，附有红斑边界的强直性解囊，舌下角化过度和碎片出血。这些临床特征在指甲中比在脚趾甲中更明显，在脚趾甲中，指甲异常不是诊断性的，并且在临床上通常无法与其他状况（尤其是甲癣）区分开。指甲牛皮癣首先会引起社会心理和美学问题，但许多患者经常抱怨功能受损。指甲牛皮癣的诊断是临床的，仅在特定情况下才需要组织病理学检查。指甲牛皮癣的病程不可预测，但是在大多数情况下，这种疾病是慢性的，完全缓解并不常见。阳光照射通常不会改善，甚至会使指甲牛皮癣恶化。没有治疗方法。根据疾病的严重程度和范围，指甲牛皮癣的治疗包括不同类型的药物，从局部治疗到全身治疗。此外，我们不应低估使用生物制剂和激光或离子电渗疗法的新疗法。这篇综述提供了针对牛皮癣的不同治疗选择以及牛皮癣患者指甲疾病的最佳管理的研究。

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