【24h】

Two's company

机译:两家公司

获取原文
           

摘要

Pairing up is sometimes paramount to life. On the molecular scale, dimerization in our bodies is at the heart of many fundamental biological processes, such as the transduction of signals from the outside of a cell to the inside for instance. Split two molecules apart and, just like taking the propeller away from a ship, things are sure to change drastically. Signal transduction, on which life depends, is hugely due to protein-protein interaction. A ligand recognises its receptor, binds to it, thereby triggering off biological processes downstream. In the case of Kit ligand, and its receptor Kit, their binding is subject to the dimerization of both the ligand and its receptor, following which signals are transduced further downstream triggering off other biological processes. Kit ligand and Kit are a case of substantial conformational change on the molecular level - dimerization but also angles which bring about flexibility - that are necessary for Kit to get on with its job.
机译:配对有时对生活至关重要。在分子尺度上,我们体内二聚化是许多基本生物学过程的核心,例如,信号从细胞外部到内部的传导。将两个分子分开,就像将螺旋桨从船上拿开一样,情况肯定会发生巨大变化。生命所依赖的信号转导很大程度上取决于蛋白质间的相互作用。配体识别其受体并与之结合,从而触发下游的生物过程。在Kit配体及其受体Kit的情况下,它们的结合会经历配体及其受体的二聚化,随后信号进一步向下游转导,触发其他生物学过程。试剂盒配体和试剂盒在分子水平上发生了显着的构象变化-二聚化以及带来灵活性的角度-这是Kit继续工作所必需的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号