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An unexpected turn of events

机译:突发事件

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Life depends on exchange. To this end, and on the cellular level, molecules are continuously secreted for the purposes of signalling, strengthening, transporting, protecting... Sometimes, the primary role of a molecule can bring about an unforeseen consequence which - if positive - is gladly preserved for the benefit of the species. This seems to be the case for a particular form of a polysaccharide known as hyaluronan: high molecular mass hyaluronan, or HMM-HA. The polymer is secreted in large quantities in a rather peculiar animal - the naked mole rat, or Heterocephalus glaber - and is thought to be responsible, at least in part, for the animal's exceptionally long life span, because of the total absence of any form of cancer. Consequently, understanding how HMM-HA achieves this - and particularly the enzyme which synthesizes it, hyaluronan synthase 2 - could pave the way to therapies able to fight off the formation of malignant tumours.
机译:生活取决于交换。为此,在细胞水平上,为了信号传导,增强,运输,保护的目的,不断分泌分子。有时,分子的主要作用会带来无法预料的后果,如果是阳性的话,很高兴地保存下来。为了物种的利益。对于被称为透明质酸的特定形式的多糖:高分子量透明质酸或HMM-HA,似乎是这种情况。该聚合物大量分泌在一种非常奇特的动物中(裸mole鼠或裸脑鼠),由于完全不存在任何形式,因此被认为至少部分负责该动物的超长寿命。癌症。因此,了解HMM-HA如何实现这一目标-尤其是合成它的酶-透明质酸合酶2-可以为能够抵抗恶性肿瘤形成的疗法铺平道路。

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