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首页> 外文期刊>Psychiatry and Clinical Psychopharmacology >The Role and Efficacy of Clozapine Treatment in Early-Onset and Very Early-Onset Schizophrenia Cases: Discussion of Five Cases
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The Role and Efficacy of Clozapine Treatment in Early-Onset and Very Early-Onset Schizophrenia Cases: Discussion of Five Cases

机译：氯氮平治疗在早发型和极早发型精神分裂症中的作用和疗效：讨论五例

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摘要

Schizophrenia is a serious mental disorder emerging at an early age, characterized by significant breakdowns in thought, perception and behavioral processes and withdrawal from human relationships. Psychopharmacologic and psychosocial approaches should be combined for the treatment of schizophrenia. Although the effects and side effects of both typical and atypical antipsychotics have been studied in adult patients in detail, studies in child and adolescent age groups are inadequate. Clozapine is a prototype of atypical antipsychotics and the first antipsychotic to be defined as atypical. Clozapine is often effective in cases in which typical and other atypical antipsychotics fail, and is accepted as the “gold standard” in the treatment of schizophrenia. In this paper, the effects and side effects of clozapine in five adolescent cases diagnosed with schizophrenia are discussed. Four of these cases showed that clozapine is effective in adolescent schizophrenia. While the four cases showing good responses to the treatment tolerated clozapine well, the other case (case 4) showed an apparent decreasing trend in neutrophil count a short while after starting the treatment and his medication was stopped at the request of his parents.
机译：精神分裂症是一种严重的精神障碍，在儿童早期就出现，其特征在于思想，知觉和行为过程的重大崩溃以及与人际关系的退缩。精神分裂症的治疗应结合心理药物学和社会心理学方法。尽管已对成年患者进行了典型和非典型抗精神病药的作用和副作用的详细研究，但在儿童和青少年年龄组的研究仍不充分。氯氮平是非典型抗精神病药的原型，也是第一个被定义为非典型抗精神病药。氯氮平通常在典型和其他非典型抗精神病药无效的情况下有效，并被视为精神分裂症的“黄金标准”。本文讨论了氯氮平在5例被诊断为精神分裂症的青少年病例中的作用和副作用。这些病例中有四个表明氯氮平对青少年精神分裂症有效。尽管四例患者对氯氮平的治疗反应良好，但另一例患者（案例4）在开始治疗后不久，中性粒细胞计数却呈明显下降趋势，并且在父母的要求下停药。

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