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首页> 外文期刊>Psychiatry Investigation >Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C
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Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C

机译：基于干扰素的丙型肝炎治疗期间情绪状态和心理健康状况变化与抑郁的关联

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Objective The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression. Methods CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits. A total of 67 treatment-na?ve patients with CHC were consecutively treated with PEG-IFN-α-2a plus ribavirin for 48 (genotype 1, n=29) or 24 (genotype 2, n=38) weeks. Patients were followed prospectively every 4 weeks during the treatment period. Results Seven patients (10.4%) were diagnosed with major depressive disorder (MDD), and eight (11.9%) developed subsyndromal depression. Times to onset of MDD and subsyndromal depression were 6.67±5.01 and 11.11±5.58 weeks, respectively, after initiation of treatment. Patients who developed MDD had significantly increased fatigue and anxiety and poor psychological well-being during the course of treatment. Pretreatment subthreshold mood symptoms were a significant predictor of depression. Conclusion An early psychiatric assessment may be helpful in improving psychological well-being in those with CHC, leading to adherence to PEG-IFN-based treatment.
机译：目的这项前瞻性研究的目的是调查在以聚乙二醇干扰素（PEG-IFN）为基础的慢性丙型肝炎（CHC）患者治疗期间情绪状态和困扰水平的暂时变化以及抑郁症的发展。我们还探讨了基线人口统计学，精神病学和人格特质是否能预测抑郁症的发展。方法对无抑郁的CHC患者进行实验室检查。精神病学访谈;并评估情绪症状，痛苦水平和人格特质。总共67名初治的CHC患者连续接受PEG-IFN-α-2a加利巴韦林治疗48周（基因型1，n = 29）或24周（基因型2，n = 38）。在治疗期间，每4周对患者进行一次前瞻性随访。结果7例（10.4％）被诊断为重度抑郁症（MDD），8例（11.9％）发生了综合征下抑郁症。开始治疗后，MDD发作时间和综合征下抑郁发作时间分别为6.67±5.01和11.11±5.58周。患有MDD的患者在治疗过程中明显增加了疲劳和焦虑感，并且心理健康状况较差。治疗前的阈下情绪症状是抑郁的重要预测指标。结论早期精神病学评估可能有助于改善CHC患者的心理健康，从而导致他们坚持以PEG-IFN为基础的治疗。

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