• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Investigation >Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder
【24h】

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

机译：BDNF Val66Met和5-HTTLPR多态性在抑郁症中的遗传作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective We investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression. Methods Final analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed. Results The 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing. Conclusion This result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.
机译：目的我们研究了抑郁症与BDNF Val66Met和5-HTTLPR之间的可能联系。脑源性神经营养因子（BDNF）基因和血清素转运蛋白（SLC6A4）基因是抑郁症有希望的候选基因。已经提出，BDNF促进了5-羟色胺能神经元的存活和分化，并且5-羟色胺能传递对BDNF基因表达具有强大的控制作用。方法对186例抑郁症患者和1032例对照组进行了最终分析。对BDNF基因的Val66Met多态性和5-羟色胺转运蛋白基因的5-HTTLPR多态性进行基因分型，并分析等位基因和基因型与抑郁症发病年龄的相关性。结果在总样本和女性中，5-HTTLPR与抑郁症的患病状态呈正相关（等位基因p = 0.038，基因型关联p = 0.015），但男性无关。 BDNF Val66Met与抑郁无关。抑郁症发作时单独使用BDNF Val66Met和5-HTTLPR与年龄无关。 BDNF Val66Met和5-HTTLPR之间相互作用的进一步分析发现，在整个患者组中，抑郁症发作时的年龄与年龄显着相关。在女性中也发现了这种关联，但在男性患者中却没有。 Bonferroni校正无法通过多次测试获得阳性结果。结论该结果表明BDNF Val66Met和5-HTTLPR可能以复杂的方式促成抑郁症，其遗传效应可能因性别而异。有必要对大量患者进行进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号