• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pulmonary Circulation >Heart Rate Recovery is an Important Predictor of Outcomes in Patients with Connective Tissue Disease–Associated Pulmonary Hypertension:
【24h】

Heart Rate Recovery is an Important Predictor of Outcomes in Patients with Connective Tissue Disease–Associated Pulmonary Hypertension:

机译：心率恢复是结缔组织病相关性肺动脉高压患者预后的重要预测指标：

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reduced heart rate recovery (HRR) after exercise is associated with increased mortality in cardiac and pulmonary diseases. We sought to evaluate the association between HRR after the 6-minute walk test (6MWT) and outcomes in patients with connective tissue disease–associated pulmonary hypertension (CTD-PH). Data were obtained by review of the medical records. HRR was defined as the difference in heart rate at the end of the 6MWT and after 1 minute (HRR1), 2 minutes (HRR2), and 3 minutes (HRR3) of rest. All patients with pulmonary hypertension and a diagnosis of systemic sclerosis, systemic lupus erythematosus, or mixed connective tissue disease who underwent the 6MWT between August 1, 2009, and October 30, 2011, were included (n = 66). By Kaplan-Meier analysis, HRR1, HRR2, and HRR3 at different cutoff points were all good predictors, with HRR1 of 16 being the best predictor of time to clinical worsening (log-rank P 0.0001), hospitalization (log-rank P = 0.0001), and survival (log-rank P 0.003). By proportional hazards regression, patients with HRR1 of 16 were at increased risk of clinical worsening (hazard ratio [HR]: 6.4 [95% confidence interval (CI): 2.6–19.2]; P 0.0001], hospitalization (HR: 6.6 [95% CI: 2.4–23]; P 0.0001), and death (HR: 4.5 [95% CI: 1.6–15.7]; P = 0.003). Patients in the highest tercile (HRR1 of ≥19) were unlikely to have a clinical worsening event (HR: 0.1 [95% CI: 0.04–0.5]; P = 0.001], to be hospitalized (HR: 0.1 [95% CI: 0.02–0.5]; P = 0.001), or to die (HR: 0.3 [95% CI: 0.07–0.9]; P = 0.04]. In conclusion, in patients with CTD-PH, abnormal HRR1 (defined as HRR1 of 16) after the 6MWT is a strong predictor of clinical worsening, time to clinical worsening, survival, and hospitalization.
机译：运动后心率恢复（HRR）降低与心脏和肺部疾病的死亡率增加相关。我们试图评估6分钟步行测试（6MWT）后HRR与结缔组织病相关性肺动脉高压（CTD-PH）患者的预后之间的关系。通过查阅病历获得数据。 HRR定义为6MWT结束时以及休息1分钟（HRR1），2分钟（HRR2）和3分钟（HRR3）之后心率的差异。纳入了所有在2009年8月1日至2011年10月30日接受6MWT的肺动脉高压诊断为系统性硬化症，系统性红斑狼疮或混合性结缔组织病的患者（n = 66）。根据Kaplan-Meier分析，不同临界点的HRR1，HRR2和HRR3都是良好的预测指标，<16的HRR1是临床恶化时间（log-rank P <0.0001），住院（log-rank P = 0.0001）和生存率（log-rank P <0.003）。通过比例风险回归，HRR1 <16的患者出现临床恶化的风险增加（风险比[HR]：6.4 [95％置信区间（CI）：2.6-19.2]; P <0.0001]，住院（HR：6.6 [95％CI：2.4–23]; P <0.0001）和死亡（HR：4.5 [95％CI：1.6–15.7]; P = 0.003）。恐怖程度最高（HRR1≥19）的患者不太可能发生临床恶化事件（HR：0.1 [95％CI：0.04-0.5]; P = 0.001]，住院（HR：0.1 [95％CI：0.02-0.5]; P = 0.001）或死亡（ HR：0.3 [95％CI：0.07-0.9]; P = 0.04]总之，在CTD-PH患者中，6MWT后HRR1异常（定义为HRR1 <16）是临床恶化时间的重要预测指标导致临床恶化，生存和住院。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号