• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pulmonary Circulation >Prevalence and Hospital Discharge Status of Human Immunodeficiency Virus–Associated Pulmonary Arterial Hypertension in the United States:
【24h】

Prevalence and Hospital Discharge Status of Human Immunodeficiency Virus–Associated Pulmonary Arterial Hypertension in the United States:

机译：在美国，人类免疫缺陷病毒相关的肺动脉高压的患病率和出院情况：

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pulmonary arterial hypertension (PAH) is a noninfectious complication of human immunodeficiency virus (HIV) infection that has gained in importance since the advent of antiretroviral therapy. HIV-associated PAH (HIV-PAH) has a higher prevalence than idiopathic PAH (IPAH), although the vascular pathology seen in HIV-PAH is virtually identical to that seen in IPAH. Initiating therapy for PAH at an early stage is associated with a better prognosis; however, because of the nonspecific symptoms associated with PAH, the diagnosis is often delayed. In addition, because of the low prevalence of HIV-PAH, routine screening for this condition has never been recommended. We hypothesize that the failure to create screening guidelines for HIV-PAH has resulted in underdiagnosis of the condition. This, in turn, results in individuals with HIV-PAH remaining undetected, allowing the disease to progress to more advanced stages or even remain unrecognized until death. If this hypothesis is correct, it may provide a strong argument for HIV-PAH screening guidelines, because HIV-PAH portends a poor prognosis and creates a significant economic burden if left untreated. To address this issue, we conducted a retrospective review of the National Hospital Discharge Survey data and the multiple-cause mortality data to determine the prevalence of HIV-PAH at hospital discharge and death. Using these large data sets, we observed that the prevalence of HIV-PAH among HIV-infected individuals at hospital discharge and death was significantly lower than the reported prevalence in the literature. In addition, we found that PAH was designated as the most common cause of mortality in patients with HIV-PAH.
机译：肺动脉高压（PAH）是人类免疫缺陷病毒（HIV）感染的一种非感染性并发症，自抗逆转录病毒疗法问世以来，这种感染已变得越来越重要。与HIV相关的PAH（HIV-PAH）的患病率高于特发性PAH（IPAH），尽管在HIV-PAH中所见的血管病理与在IPAH中所见基本相同。早期开始PAH的治疗预后较好。但是，由于与PAH相关的非特异性症状，诊断通常会延迟。此外，由于HIV-PAH的患病率较低，因此从未建议对此情况进行常规筛查。我们假设未能建立针对HIV-PAH的筛查指南会导致对该病的诊断不足。反过来，这导致HIV-PAH的个体未被发现，从而使疾病发展到更晚期，甚至直到死亡都未被发现。如果此假设正确，则可能为HIV-PAH筛查指南提供有力的论据，因为HIV-PAH预后不良，如果不加以治疗，会带来巨大的经济负担。为了解决这个问题，我们对国家医院出院调查数据和多原因死亡率数据进行了回顾性审查，以确定在医院出院和死亡时HIV-PAH的患病率。使用这些大数据集，我们观察到在出院和死亡的HIV感染者中HIV-PAH的患病率明显低于文献中报道的患病率。此外，我们发现PAH被指定为HIV-PAH患者最常见的死亡原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号