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首页> 外文期刊>Universal Journal of Clinical Medicine >Comparative Anthelmintic Efficacy of Caesalpinia Crista, Nigella Sativa and Oxfendazole in Broilers with Experimentally Induced Ascaridia Galli Infection
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Comparative Anthelmintic Efficacy of Caesalpinia Crista, Nigella Sativa and Oxfendazole in Broilers with Experimentally Induced Ascaridia Galli Infection

机译：肉仔鸡Cri虫，苜蓿苜蓿和奥芬达唑在肉鸡实验性A虫感染中的驱虫效果比较

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The study was conducted to explore the effect of two herbal drugs, Caesalpinia crista and Nigella sativa in comparison with Oxfendazole in broilers experimentally induced with Ascaridia galli infection .A total of 130 day old broiler chicks were divided into five groups i.e. A, B, C, D and E each group having 26 birds. Group E was kept as negative control, while all other groups were induced with experimental Ascardia galli infection on 15th day. Group A was kept as positive control and groups B and C were treated with Caesalpinia crista and Nigella sativa as methanolic extract orally once @50mg/kg body weight and group D was medicated with Oxfendazole @10mg/kg body weight orally once on 25th day post infection. On 25th day post infection before treatment 4 birds from each group were slaughtered, and worm count was done. The efficacy was confirmed by counting the worm, slaughtering all the bird on 30th day post infection. The mean worm count was significantly different (p<0.05) between the treated and non treated groups. The efficacy of the plant extracts were less as compare to Oxfendazole. The efficacy of Caesalpinia crista and Nigella sativa was 70.83% and 57.5% respectively while the efficacy of Oxfendazole was 90.83%.In vitro treatment at 37±1℃ revealed that a serial dose of the plant extract caused dose-dependent vermicidal effect on the worm (significant efficacy at P<0.05), except at the lowest dose (i.e. 5 mg/mL). The efficacy of drugs was calculated on the basis of reduction in total worm count after treatment.
机译：这项研究旨在探讨两种草药，即es草和苜蓿与苜蓿草酸芬达唑相比，在实验性感染加里氏infection虫的肉鸡中的作用。将总共130日龄的肉鸡分为A，B，C五组，D和E各有26只鸟。将E组作为阴性对照，而所有其他组在第15天用实验性加斯卡迪氏菌感染诱导。 A组作为阳性对照，B和C组以Caesalpinia crista和Nigella sativa作为甲醇提取物口服，剂量为50mg / kg体重一次，D组于术后第25天口服奥芬达唑，剂量为10mg / kg一次。感染。治疗前感染后第25天，每组宰杀4只家禽，并进行蠕虫计数。通过对蠕虫计数，在感染后第30天宰杀所有家禽，证实了疗效。在治疗组和未治疗组之间，平均蠕虫数显着不同（p <0.05）。与奥芬达唑相比，植物提取物的功效较低。 es草和苜蓿的功效分别为70.83％和57.5％，奥芬达唑的功效为90.83％。在37±1℃的体外处理显示，一系列剂量的植物提取物对蠕虫有剂量依赖性的杀线作用（在P <0.05时有显着疗效），但最低剂量（即5 mg / mL）除外。根据治疗后蠕虫总数的减少来计算药物的功效。

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