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首页> 外文期刊>Pulmonary Circulation >Acute Effects of Levosimendan in Experimental Models of Right Ventricular Hypertrophy and Failure:
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Acute Effects of Levosimendan in Experimental Models of Right Ventricular Hypertrophy and Failure:

机译：左西孟旦在右室肥大和衰竭实验模型中的急性作用：

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Pulmonary arterial hypertension (PAH) is a fatal disease, and the ultimate cause of death is right ventricular (RV) failure. In this study, we investigated the acute hemodynamic effects of levosimendan in two rat models of RV hypertrophy and failure. Wistar rats were randomized to receive sham surgery (n = 8), pulmonary trunk banding (PTB; n = 8), or monocrotaline injection (MCT; n = 7). RV function was evaluated at baseline and after injection of placebo and two concentrations of levosimendan (12 and 60 μg/kg) using magnetic resonance imaging, echocardiography, and invasive pressure recordings. PTB and MCT injection caused hypertrophy, dilatation, and failure of the RV compared with sham surgery. Levosimendan increased RV end systolic pressure (sham surgery: 16.0% ± 3.8% [P = 0.0038]; MCT: 9.9% ± 3.1% [P = 0.018]; PTB: 24.5% ± 3.3% [P = 0.0001]; mean ± SEM) compared with placebo. Levosimendan markedly increased RV stroke volume (SV) in the MCT group (29.1% ± 8.3%; P = 0.012), did not change RV SV in the PTB group (0.4% ± 4.5%; P = 0.93), and decreased RV SV in the sham surgery group (?10.9% ± 3.7%; P = 0.020). Nitroprusside, which was used to mimic the systemic arterial vasodilator action of levosimendan, did not influence RV function. These data demonstrate that levosimendan acutely improves the failing right heart in a MCT model of PAH and that the mechanism involves a direct acute positive inotropic effect on the hypertrophic and failing RV of the rat.
机译：肺动脉高压（PAH）是一种致命疾病，其最终死亡原因是右心室（RV）衰竭。在这项研究中，我们调查了左西孟旦在两种RV肥大和衰竭模型中的急性血液动力学作用。 Wistar大鼠随机接受假手术（n = 8），肺动脉束带术（PTB; n = 8）或单芥子碱注射（MCT; n = 7）。使用磁共振成像，超声心动图和有创压力记录，在基线时和注射安慰剂和两种浓度的左西孟旦（12和60μg/ kg）后评估RV功能。与假手术相比，PTB和MCT注射可导致RV肥大，扩张和衰竭。左西孟旦增加右室末端收缩压（假手术：16.0％±3.8％[P = 0.0038]; MCT：9.9％±3.1％[P = 0.018]; PTB：24.5％±3.3％[P = 0.0001];平均值±SEM ）与安慰剂相比。左西孟旦在MCT组中显着增加RV卒中量（SV）（29.1％±8.3％; P = 0.012），在PTB组中未改变RV SV（0.4％±4.5％; P = 0.93），而RV SV降低在假手术组中（？10.9％±3.7％; P = 0.020）。硝普钠被用来模拟左西孟旦的全身性血管舒张作用，但不影响RV功能。这些数据表明左西孟旦能急性改善PAH的MCT模型中右心脏衰竭，并且该机制涉及对大鼠肥大和衰竭RV的直接急性正性肌力作用。

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