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首页> 外文期刊>Pulmonary Circulation >Assessment of the Physiologic Contribution of Right Atrial Function to Total Right Heart Function in Patients with and without Pulmonary Arterial Hypertension:
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Assessment of the Physiologic Contribution of Right Atrial Function to Total Right Heart Function in Patients with and without Pulmonary Arterial Hypertension:

机译：评估有无肺动脉高压患者右心房功能对总右心功能的生理贡献：

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Total right heart function requires normal function of both the right ventricle and the right atrium. However, the degree to which right atrial (RA) function and right ventricular (RV) function each contribute to total right heart function has not been quantified. In this study, we aimed to quantify the contribution of RA function to total right heart function in a group of pulmonary arterial hypertension (PAH) patients compared to a cohort of normal controls without cardiovascular disease. The normal cohort comprised 35 subjects with normal clinical echocardiograms, while the PAH cohort included 37 patients, of whom 31 had echocardiograms before and after initiation of PAH-specific therapy. Total right heart function was measured via tricuspid annular plane excursion (TAPSE). TAPSE was broken down into two components, the excursion occurring during RA contraction (TAPSERA) and that occurring before RA contraction (TAPSERV). RA fractional area change (RA-FAC) was also compared between the two groups. In the PAH cohort, more than half of the total TAPSE occurred during atrial systole, compared to less than one-third in the normal cohort (51.0% vs. 32.1%; P 0.0001). There was a significant correlation between RA-FAC and TAPSE in the PAH cohort but not in the normal cohort. TAPSE improved significantly in the posttreatment cohort (1.7 vs. 2.1 cm), but TAPSERA continued to account for about half of the total TAPSE after treatment. RA function accounts for a significantly greater proportion of total right heart function in patients with PAH than in normal subjects.
机译：完整的右心功能需要右心室和右心房都正常。但是，右心房（RA）功能和右心室（RV）功能分别对总的右心功能的贡献程度尚未确定。在这项研究中，我们旨在量化与一组没有心血管疾病的正常对照相比，一组肺动脉高压（PAH）患者中RA功能对总右心功能的贡献。正常队列包括35名临床超声心动图正常的受试者，而PAH队列包括37名患者，其中31名在开始进行PAH特异性治疗前后有超声心动图。通过三尖瓣环平面偏移（TAPSE）测量总的右心功能。 TAPSE分为两个部分，偏移发生在RA收缩期间（TAPSERA）和偏移发生在RA收缩之前（TAPSERV）。还在两组之间比较了RA分数面积变化（RA-FAC）。在PAH队列中，TAPSE总数的一半以上发生在心室收缩期，而正常队列中则少于三分之一（51.0％对32.1％; P <0.0001）。在PAH队列中，RA-FAC与TAPSE之间存在显着相关性，而在正常队列中则没有。 TAPSE在治疗后队列中有显着改善（1.7比2.1 cm），但是TAPSERA仍占治疗后TAPSE总数的一半左右。与正常人相比，RAH在PAH患者中占总右心功能的比例明显更高。

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