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首页> 外文期刊>Pulmonary Circulation >Statement on Pregnancy in Pulmonary Hypertension from the Pulmonary Vascular Research Institute:
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Statement on Pregnancy in Pulmonary Hypertension from the Pulmonary Vascular Research Institute:

机译：肺血管研究所发表的关于肺动脉高压妊娠的声明：

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Pregnancy outcomes in patients with pulmonary hypertension remain poor despite advanced therapies. Although consensus guidelines recommend against pregnancy in pulmonary hypertension, it may nonetheless occasionally occur. This guideline document sought to discuss the state of knowledge of pregnancy effects on pulmonary vascular disease and to define usual practice in avoidance of pregnancy and pregnancy management. This guideline is based on systematic review of peer-reviewed, published literature identified with MEDLINE. The strength of the literature was graded, and when it was inadequate to support high-level recommendations, consensus-based recommendations were formed according to prespecified criteria. There was no literature that met standards for high-level recommendations for pregnancy management in pulmonary hypertension. We drafted 38 consensus-based recommendations on pregnancy avoidance and management. Further, we identified the current state of knowledge on the effects of sex hormones during pregnancy on the pulmonary vasculature and right heart and suggested areas for future study. There is currently limited evidence-based knowledge about both the basic molecular effects of sex hormones and pregnancy on the pulmonary vasculature and the best practices in contraception and pregnancy management in pulmonary hypertension. We have drafted 38 consensus-based recommendations to guide clinicians in these challenging topics, but further research is needed in this area to define best practices and improve patient outcomes.
机译：尽管有先进的治疗方法，但肺动脉高压患者的妊娠结局仍然较差。尽管共识指南建议不要在肺动脉高压中妊娠，但仍可能偶尔发生。本指南文件旨在探讨妊娠对肺血管疾病的影响的知识状态，并定义避免妊娠和避免妊娠管理的常规做法。该指南基于对MEDLINE识别的同行评审，已发表文献的系统评价。文献的强度是分级的，当不足以支持高级建议时，会根据预先指定的标准形成基于共识的建议。没有文献符合肺动脉高压妊娠管理高水平建议的标准。我们就避免和管理妊娠问题起草了38项基于共识的建议。此外，我们确定了怀孕期间性激素对肺血管和右心的影响的最新知识，并提出了需要进一步研究的领域。目前，关于性激素和妊娠对肺血管的基本分子作用以及肺动脉高压避孕和妊娠管理的最佳实践的基于证据的知识有限。我们已经起草了38项基于共识的建议，以指导临床医生应对这些具有挑战性的主题，但是需要在这一领域进行进一步研究，以定义最佳实践并改善患者预后。

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