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首页> 外文期刊>Pulmonary therapy. >Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data
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Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

机译：雾化器设计对无创机械通气期间气雾剂输送的影响：体外数据建模研究

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IntroductionNebulizers used to deliver aerosol during non-invasive mechanical ventilation (NIV) have many types, each type has many different designs. This study aimed to determine the effect of nebulizer deign on aerosol delivery in NIV. MethodsDifferent designs of jet nebulizer (JN) and vibrating mesh nebulizer (VMN) were tested by placing 1?ml of salbutamol in a nebulizer chamber operated in an in vitro NIV setting using a breathing simulator with adult settings (inhalation–exhalation ratio 1:3, 15 breaths/min and tidal volume 500?ml) and mechanical ventilator (MV) set at spontaneous mode with a peak inspiratory pressure of 20?cm H2O and a peak expiratory pressure of 5?cm H2O. Inhalation filters were placed before the breathing simulator to collect emitted aerosol (inhalable dose). Also, amounts of drug left in nebulizer chamber (residual dose) were collected and analyzed for salbutamol content. Statistical data analysis and modeling was performed on the results. ResultsThe vibrating mesh nebulizer delivered significantly higher inhalable doses and lower residual dose compared to JN ( p p ConclusionsNebulizer design has a great role in efficacy of JN but not VMN and different types of JN should not considered interchanges without dose adjustment. Modeling can optimize these results for better aerosol delivery.
机译：简介用于在无创机械通气（NIV）期间输送气雾剂的雾化器有多种类型，每种类型都有许多不同的设计。这项研究旨在确定雾化器设计对NIV中气雾剂输送的影响。方法通过使用成人设置的呼吸模拟器（吸入-呼出比为1：3）将1？ml沙丁胺醇放在体外NIV设置的雾化器室中，对喷射雾化器（JN）和振动筛网雾化器（VMN）的不同设计进行测试，每分钟15次呼吸，潮气量500？ml）和机械呼吸机（MV）设置为自发模式，吸气峰值为20？cm H 2 O，呼气峰值为5？cm H 2 O。将吸入过滤器放在呼吸模拟器之前，以收集散发的气溶胶（可吸入剂量）。同样，收集留在雾化室中的药物量（剩余剂量）并分析沙丁胺醇含量。对结果进行统计数据分析和建模。结果与JN相比，振动式网状雾化器可吸入剂量高，残留剂量低（pp结论）雾化器设计在JN的功效上起着重要作用，但对VMN不起作用，不同类型的JN不应在不调整剂量的情况下考虑互换使用。更好的气雾剂输送。

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