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Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane

机译：重原子增强室温磷光法测定痕量痕量的痕量

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Harmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed for substrates containing 46 ng of harmane. Such sensitivity and precision are needed because harmane intake must be strictly controlled to achieve proper therapeutic response. Interference studies were performed using thalidomide, reserpine and yohimbine. Recovery of 104±6% was achieved using solid surface room-temperature phosphorimetry. The result was comparable to the one obtained by micellar electrokinetic chromatography.
机译：已建议使用Harmane来治疗癫痫，艾滋病和湿疹病。它的室温磷光是使用AgNO3或TlNO3诱导的，分别能实现0.12和2.4 ng的绝对检测极限，线性动态范围扩展到456 ng（AgNO3）和911 ng（TlNO3）。对于包含46 ng harmane的底物，观察到相对标准偏差约为3％。之所以需要这样的灵敏度和精确度，是因为必须严格控制烷烃的摄入，以实现适当的治疗反应。使用沙利度胺，利血平和育亨宾进行干预研究。使用固体表面室温磷光法可实现104±6％的回收率。结果与通过胶束电动色谱法获得的结果相当。

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