A reproducible method for obtaining a 2-arms monofunctional peg with high purity

Castro Fidel R.; Centro de Ingeniería Genética y Biotecnología Ciudad de La Habana Cuba; Colás Rosa M.; Páez Rolando; Peniche Carlos; Ramón José A.; Sáez Vivian M.; Universidad de La Habana Ciudad de La Habana Cuba

首页> 外文期刊>Quimica nova >A reproducible method for obtaining a 2-arms monofunctional peg with high purity

【24h】

A reproducible method for obtaining a 2-arms monofunctional peg with high purity

机译：一种获得高纯度2臂单功能钉的可重现方法

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

PEGylation has become a widely applied technique to enhancing in vitro and in vivo stability of therapeutic proteins and to increasing materials biocompatibility. PEG branched structures have proven useful for protein and peptide modification. Furthermore, they may be better than linear structures for many purposes. This paper describes an improved procedure for obtaining 2-arms PEG based on L-lysine. The efficiency of the synthesis was not related to moisture of the raw materials. This procedure does not use hazardous reagents as previous protocols do. It implemented a purification process for obtaining the desired structure with high purity ( 99%). Finally, the procedure described here allows the obtaining of others PEGylation reagents.

机译：聚乙二醇化已成为一种广泛应用的技术，用于增强治疗性蛋白质的体外和体内稳定性并提高材料的生物相容性。已证明PEG支链结构可用于蛋白质和肽的修饰。此外，在许多方面，它们可能比线性结构更好。本文介绍了一种基于L-赖氨酸获得2臂PEG的改进方法。合成效率与原料的水分无关。此过程不使用以前的规程使用危险试剂。它实施了纯化工艺，以获得所需的高纯度（> 99％）结构。最后，此处描述的过程允许获得其他PEG化试剂。

著录项

来源
《Quimica nova》 |2009年第6期|共页
作者
Castro Fidel R.; Centro de Ingeniería Genética y Biotecnología Ciudad de La Habana Cuba; Colás Rosa M.; Páez Rolando; Peniche Carlos; Ramón José A.; Sáez Vivian M.; Universidad de La Habana Ciudad de La Habana Cuba;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. A reproducible method for obtaining a 2-arms monofunctional peg with high purity [J] . Castro Fidel R., Centro de Ingeniería Genética y Biotecnología Ciudad de La Habana Cuba, Colás Rosa M., Quimica nova . 2009,第6期

机译：一种获得高纯度2臂单功能钉的可重现方法
2. Effective methods for obtaining good points for quadrature in reproducing kernel Hilbert spaces [J] . Ryunosuke Oshiro, Kenichiro Tanaka JSIAM Letters . 2020,第1期

机译：在再现核心克尔伯特空间中获得正交点的有效方法
3. Methods for obtaining reliable and reproducible results in studies of Candida biofilms formed in vitro [J] . CostaA.C.B.P., PereiraC.A., FreireF., Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2013,第6期

机译：在体外念珠菌生物膜研究中获得可靠和可再现结果的方法
4. Methods of obtaining of high purity TNT [C] . Z. Matys, D. Powala, A. Orzechowski, Seminar on New Trends in Research of Energetic Materials . 2014

机译：获得高纯度TNT的方法
5. The development of an ion-molecule reaction-based mass spectometric method for the identification of protonated monofunctional nitrogen-containing compounds and a study on the chemical reactivity of o-benzyne derivatives by using Fourier transform ion cyclotron resonance mass spectrometry (FT -ICR). [D] . Campbell, Karinna Marie. 2007

机译：基于离子分子反应的质谱法用于质子化单官能含氮化合物鉴定的研究进展，以及通过傅立叶变换离子回旋共振质谱（FT -ICR）研究邻苯并ne衍生物的化学反应性。
6. A reproducible method to enrich membrane proteins with high-purity and high-yield for an LC-MS/MS approach in quantitative membrane proteomics [O] . Xianyin Lai -1

机译：一种可重复的方法以富含高纯度和高产的用于定量膜蛋白质组学中的LC-MS / MS方法的高产蛋白质
7. Un método reproducible para obtener peg biramificado monofuncional de alta pureza A reproducible method for obtaining a 2-arms monofunctional peg with high purity [O] . José A. Ramón, Carlos Peniche, Fidel R. Castro, 2009

机译：获得高纯度单官能双支柱的可重复方法获得高纯度双臂单功能桩的可重复方法

A reproducible method for obtaining a 2-arms monofunctional peg with high purity

摘要

著录项

相似文献

相关主题

期刊订阅