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Compostos organofosforados pentavalentes: histórico, métodos sintéticos de prepara??o e aplica??es como inseticidas e agentes antitumorais

机译:五价有机磷酸盐化合物:杀虫剂和抗肿瘤剂的历史,合成制备方法和应用

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This paper is a review of the history, synthesis and application of organophosphorus compounds, especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates, phosphonates and phosphonic acids with insecticide and anticancer activities. The organophosphorus compounds with agrochemical applications show great structural variety, They include not only insecticides, but also fungicides, herbicides, and others. The large variety of commercially available organophosphorus pesticides is remarkable. Even more interesting is the high efficiency of some organophosphorus compounds as anticancer agents such as cyclophosphamide and its derivatives.
机译:本文综述了有机磷化合物的历史,合成和应用,特别是五价磷化合物的历史,合成和应用,例如具有杀虫剂和抗癌活性的氨基磷酸酯,硫代磷酸酯,膦酸酯和膦酸。具有农业化学应用的有机磷化合物显示出极大的结构多样性,它们不仅包括杀虫剂,还包括杀真菌剂,除草剂等。大量可商购的有机磷农药是引人注目的。更有趣的是某些有机磷化合物作为抗癌剂(例如环磷酰胺及其衍生物)的高效性。

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