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首页> 外文期刊>Ukrainian Biochemical Journal >Nitrate and nitrite in drinking water affect antioxidant enzymes in erythrocytes of rats
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Nitrate and nitrite in drinking water affect antioxidant enzymes in erythrocytes of rats

机译：饮用水中的硝酸盐和亚硝酸盐影响大鼠红细胞中的抗氧化酶

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The present study evaluated the effect of short term intake of nitrite and nitrate drinking water on the antioxidant system and membrane damage of rat erythrocytes. Wistar rats were randomly divided into three groups as follows; the group I received only distilled water ad libitum; the group II was given water with nitrate (a dose of 124 mg/kg of nitrate-nitrogen) as drinking water and the group III was given nitrites dissolved in distilled water in a dose of 150 mg/kg for 7 days. At the end of the study, group III rats showed a significant decrease in activities of glutathione peroxidase (GPx), glucose 6-phosphate dehydrogenase (G6PDH) and catalase (CAT), while in group II rats, the activity of GPx and CAT were significantly reduced, but no significant changes in glutathione reductase activity and peroxynitrite levels were observed. On the other hand, malondialdehyde (MDA) was increased in both groups with respect to group I. Also, our major results?indicate that all treatments changed methemoglobin levels and osmotic fragility in comparison to group I rats. The intensity of alterations was found more severe in rats of group III, followed by rats of group II. It can be concluded from these observations that nitrate or nitrite leads to alterations in the erythrocytes antioxidant defense status mainly throughout NADPH relate enzymes.
机译：本研究评估了短期摄入亚硝酸盐和硝酸盐饮用水对大鼠抗氧化系统和大鼠红细胞膜损伤的影响。将Wistar大鼠随机分为以下三组：我只随意喝了蒸馏水的小组;给第二组喝含硝酸盐的水（剂量为124 mg / kg的硝酸盐氮）作为饮用水，给第三组使用溶解于蒸馏水中的亚硝酸盐，剂量为150 mg / kg，持续7天。在研究结束时，III组大鼠的谷胱甘肽过氧化物酶（GPx），6-磷酸葡萄糖脱氢酶（G6PDH）和过氧化氢酶（CAT）的活性显着降低，而II组大鼠中GPx和CAT的活性显着降低。谷胱甘肽还原酶活性和过氧亚硝酸盐水平显着降低，但未见明显变化。另一方面，与I组相比，两组的丙二醛（MDA）均增加。而且，我们的主要结果表明，与I组大鼠相比，所有治疗均改变了高铁血红蛋白水平和渗透脆性。发现改变的强度在第三组的大鼠中更严重，其次是第二组的大鼠。从这些观察结果可以得出结论，硝酸盐或亚硝酸盐导致红细胞抗氧化防御状态的改变，主要贯穿整个NADPH相关酶。

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