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首页> 外文期刊>Ukrainian Biochemical Journal >Mg(2+),ATP-dependent plasma membrane calcium pump of smooth muscle cells. ??. Regulation of activity
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Mg(2+),ATP-dependent plasma membrane calcium pump of smooth muscle cells. ??. Regulation of activity

机译：Mg（2 +），ATP依赖性的平滑肌细胞质膜钙泵。 ??。活动监管

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摘要

Plasma membrane Casup2+/sup-pump is one of key proteins, which takes part in Casup2+/sup exchange in smooth muscle cells. It has a lot of diverse functions from control of basal cytoplasmal Casup2+/sup concentration to regulation of proteins involved in Casup2+/sup-dependent signal pathway. Casup2+/sup pump function is often dependent on the isoform or even form of alternative splicing. Allowing for a variety of Casup2+/sup-pump functions and properties, which were reviewed in detail in the first part of our review article cycle (Ukr. Biochem. J., 2015; 87(1)), the precise control of the mentioned pump activity is very important for cell functioning. The other part of this article is dedicated to different regulation factors of smooth muscle plasma membrane Casup2+/sup-pump activity: endogenous and exogenous, biotic and abiotic factors. Special attention is given to literature data and own results about design and the search of selective plasma membrane Casup2+/sup-pump inhibitor which would allow examining its functioning in smooth muscle cells more meticulously.
机译：质膜Ca 2 + -泵是关键蛋白之一，参与平滑肌细胞Ca 2 + 的交换。它具有许多不同的功能，从控制基础细胞质Ca 2 + 的浓度到调节与Ca 2 + 依赖的信号通路有关的蛋白质。 Ca 2 + 泵功能通常取决于同种型甚至替代剪接形式。允许多种Ca 2 + 泵功能和特性，这些在我们的评论文章周期的第一部分中进行了详细介绍（Ukr。Biochem。J.，2015; 87（1）） ，精确控制提到的泵活动对于细胞功能非常重要。本文的另一部分专门讨论平滑肌质膜Ca 2 + -泵的不同调节因子：内源性和外源性，生物和非生物因子。特别注意文献数据和有关设计以及选择性质膜Ca 2 + -泵抑制剂的研究本身的结果，这将使我们能够更仔细地检查其在平滑肌细胞中的功能。

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