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Scientific and practical activity of the Department of Molecular Biology of the Palladin Institute of Biochemistry of NAS of Ukraine

机译：乌克兰NAS帕拉丁生物化学研究所分子生物学系的科学和实践活动

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The present paper gives a detailed analysis of scientific and practical activity of the Department of Molecular Biology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its development. The most important results of the research of molecular mechanisms of regulation of glycolysis and gene expression in malignant tumors upon hypoxia; identification of key transcription factors of the regulation of proliferation and the role of alternative splicing in the regulation of the activity of the different PFKFB isoforms are reported. In recent years, the efforts of the department’s staff have been focused on studying the role of endoplasmic reticulum stress and the regulation of metabolism and proliferation processes at the level of gene expression in genome reprogramming. The obtained results allow to establish the molecular bases of pathogenesis of various diseases and to develop new effective methods for their diagnosis, prevention and treatment.
机译：本文根据其发展历史对乌克兰NAS帕拉丁生物化学研究所分子生物学系的科学和实践活动进行了详细分析。缺氧时恶性肿瘤糖酵解和基因表达调控分子机制研究的最重要结果;报道了调节增殖的关键转录因子的鉴定以及选择性剪接在不同PFKFB同工型活性调节中的作用。近年来，该部门员工的工作重点一直放在研究内质网应激的作用以及在基因组重编程中基因表达水平上对代谢和增殖过程的调节。获得的结果可以建立各种疾病的发病机理的分子基础，并为诊断，预防和治疗开发新的有效方法。

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