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首页> 外文期刊>Upsala journal of medical sciences >Evaluation of the Teratogenic Potential of Pyrazinamide in Wistar Rats
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Evaluation of the Teratogenic Potential of Pyrazinamide in Wistar Rats

机译：吡嗪酰胺对Wistar大鼠致畸作用的评估

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We have tested Pyrazinamide (PZA), an essential component of modern short-course tuberculosis treatment regimen, for teratogenicity using Wistar rats. The drug was given by oral intubation from 6–15 days of gestation, at doses of 0, 25, 100 and 500 mg/kg body weight per day. Reduction in body weight and food consumption were observed in the treated dams. On day 20 of gestation, all the dams were killed by cervical dislocation and signs of maternal toxicity, reproductive indices and fetal measurements were recorded. Dams given doses of 100 and 500 mg/kg had significantly higher incidence of reabsorbed fetuses, reduced litter size, and impaired neonatal growth than those given no PZA or only 25 mg/kg dose. External visceral and skeletal examination of all fetuses of PZA-treated dams showed several types of variations which were neither dose related nor having a consistent pattern. However, these variations occurred mostly in the dams treated with the dose of 500 mg/kg. In conclusion, these data show that in Wistar rats, only high doses of PZA (100 and 500 mg/kg) produced fetotoxicity. No evidence of teratogenic effect of the drug was observed.
机译：我们已经使用Wistar大鼠测试了吡嗪酰胺（PZA）（它是现代短程结核病治疗方案的重要组成部分）的致畸性。妊娠6–15天通过口服插管给药，每天剂量为0、25、100和500 mg / kg体重。在经过处理的水坝中，体重和食物消耗减少。在妊娠的第20天，所有大坝都因颈脱位而被杀死，并记录了母体毒性，生殖指数和胎儿测量的体征。与未给予PZA或仅给予25 mg / kg的水坝相比，给予100和500 mg / kg的水坝的胎儿被重吸收的几率，产仔数减少和新生儿生长受损显着更高。经PZA处理的大坝的所有胎儿的外部内脏和骨骼检查显示出几种类型的变异，这些变异既与剂量无关，也不具有一致的模式。但是，这些变化大多发生在以500 mg / kg的剂量处理过的水坝中。总之，这些数据表明，在Wistar大鼠中，只有高剂量的PZA（100和500 mg / kg）会产生胎儿毒性。没有观察到药物有致畸作用的证据。

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