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首页> 外文期刊>Pathology and Laboratory Medicine International >Frequency of anti-glycoprotein Ia/IIa (anti-HPA-5b,-5a) and anti-glycoprotein IIb/IIIa (anti-HPA-1a,-3a,-4a) alloantibodies in multiparous women of African descent
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Frequency of anti-glycoprotein Ia/IIa (anti-HPA-5b,-5a) and anti-glycoprotein IIb/IIIa (anti-HPA-1a,-3a,-4a) alloantibodies in multiparous women of African descent

机译：非洲裔多族妇女抗糖蛋白Ia / IIa（抗HPA-5b，-5a）和抗糖蛋白IIb / IIIa（抗HPA-1a，-3a，-4a）同种抗体的发生频率

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Background: Human platelet antibodies are often implicated in some disease conditions, such as neonatal alloimmune thrombocytopenia (NAIT), idiopathic thrombocytopenic purpura (ITP) and platelet refractoriness. The frequencies of these alloantibodies have not been reported in Nigeria and West Africa.Methods: Screening for allontibodies to human platelet antigens (HPA) was undertaken using the GTI PakPlus? qualitative solid phase ELISA reagent. Platelet count was done using the ICSH approved procedure using 1% ammonium oxalate reagent.Study design: A cross-section of apparently healthy adult Nigerian multiparous non-pregnant women, who were staff of a tertiary health facility in the Niger Delta, Nigeria, were screened for alloantibodies to human platelet antigens.Results: Of the one hundred (100) women screened, the prevalence of anti-glycoprotein IIb/IIIa (anti-HPA-Ia,-3a,-4a) was zero percent (0%), anti-glycoprotein Ia/IIa (anti-HPA-5b) accounted for 30% of results, while anti-glycoprotein Ia/IIa (anti-HPA-5a) was 18%. Parity was found to exert significant influence on the development to HPA antibodies (Fisher’s Exact Test = 11.683, P 0.05).Conclusion: This study has observed a high prevalence of anti-HPA-5b in our sample population. The prevalence of alloantibodies to HPA antigens was found to associate strongly with parity. These results indicate that there is a need to initiate platelet serology in our tertiary health institutions, as well as educate our women on the risk associated with frequent pregnancies, and ensure that adequate caution is taken when recruiting multiparous women as blood donors.
机译：背景：人血小板抗体通常与某些疾病有关，例如新生儿同种免疫血小板减少症（NAIT），特发性血小板减少性紫癜（ITP）和血小板不应性。这些同种抗体的频率在尼日利亚和西非尚无报道。方法：使用GTI PakPlus筛选人血小板抗原（HPA）的同种抗体。定性固相ELISA试剂。血小板计数是通过ICSH批准的程序，使用1％的草酸铵试剂进行的。研究设计：横断面貌健康的尼日利亚多产非孕妇，她们是尼日利亚尼日尔三角洲的一家三级医疗机构的工作人员。结果：在一百（100）名妇女中，抗糖蛋白IIb / IIIa（抗HPA-Ia，-3a，-4a）的患病率为零（0％），抗糖蛋白Ia / IIa（抗HPA-5b）占结果的30％，而抗糖蛋白Ia / IIa（抗HPA-5a）占18％。发现奇偶性对HPA抗体的发育有重要影响（Fisher精确检验= 11.683，P 0.05）。结论：这项研究发现我们样本人群中抗HPA-5b的流行率很高。发现同种异体抗体对HPA抗原的患病率与胎次密切相关。这些结果表明，有必要在我们的三级医疗机构中进行血小板血清学检查，并对妇女进行频繁怀孕相关的风险教育，并确保在招募多胎妇女作为献血者时要采取足够的谨慎态度。

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