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首页> 外文期刊>Polymers >Novel Electrospun Polylactic Acid Nanocomposite Fiber Mats with Hybrid Graphene Oxide and Nanohydroxyapatite Reinforcements Having Enhanced Biocompatibility
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Novel Electrospun Polylactic Acid Nanocomposite Fiber Mats with Hybrid Graphene Oxide and Nanohydroxyapatite Reinforcements Having Enhanced Biocompatibility

机译：具有增强的生物相容性的混合石墨烯氧化物和纳米羟基磷灰石增强的新型电纺聚乳酸纳米复合纤维毡

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Graphene oxide (GO) and a nanohydroxyapatite rod (nHA) of good biocompatibility were incorporated into polylactic acid (PLA) through electrospinning to form nanocomposite fiber scaffolds for bone tissue engineering applications. The preparation, morphological, mechanical and thermal properties, as well as biocompatibility of electrospun PLA scaffolds reinforced with GO and/or nHA were investigated. Electron microscopic examination and image analysis showed that GO and nHA nanofillers refine the diameter of electrospun PLA fibers. Differential scanning calorimetric tests showed that nHA facilitates the crystallization process of PLA, thereby acting as a nucleating site for the PLA molecules. Tensile test results indicated that the tensile strength and elastic modulus of the electrospun PLA mat can be increased by adding 15 wt % nHA. The hybrid nanocomposite scaffold with 15 wt % nHA and 1 wt % GO fillers exhibited higher tensile strength amongst the specimens investigated. Furthermore, nHA and GO nanofillers enhanced the water uptake of PLA. Cell cultivation, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and alkaline phosphatase tests demonstrated that all of the nanocomposite scaffolds exhibit higher biocompatibility than the pure PLA mat, particularly for the scaffold with 15 wt % nHA and 1 wt % GO. Therefore, the novel electrospun PLA nanocomposite scaffold with 15 wt % nHA and 1 wt % GO possessing a high tensile strength and modulus, as well as excellent cell proliferation is a potential biomaterial for bone tissue engineering applications.
机译：通过静电纺丝将氧化石墨烯（GO）和具有良好生物相容性的纳米羟基磷灰石棒（nHA）掺入聚乳酸（PLA）中，以形成用于骨组织工程应用的纳米复合纤维支架。研究了用GO和/或nHA增强的电纺PLA支架的制备，形态，机械和热性能以及生物相容性。电子显微镜检查和图像分析表明，GO和nHA纳米填料改善了电纺PLA纤维的直径。差示扫描量热测试表明，nHA促进了PLA的结晶过程，从而充当了PLA分子的成核位点。拉伸试验结果表明，通过添加15wt％的nHA可以增加电纺PLA毡的拉伸强度和弹性模量。在研究的样品中，具有15 wt％nHA和1 wt％GO填料的杂化纳米复合材料支架表现出更高的拉伸强度。此外，nHA和GO纳米填料提高了PLA的吸水率。细胞培养，3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）和碱性磷酸酶测试表明，所有纳米复合材料支架均比纯PLA垫具有更高的生物相容性，特别是对于支架具有15 wt％的nHA和1 wt％的GO。因此，具有15重量％的nHA和1重量％的GO的新型电纺PLA纳米复合支架具有高的拉伸强度和模量，以及优异的细胞增殖，是用于骨组织工程应用的潜在生物材料。

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