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Sialic Acid-Targeted Biointerface Materials and Bio-Applications

机译：唾液酸靶向的生物界面材料和生物应用

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Sialic acids (SAs) are typically found as terminal monosaccharides attached to cell surface glycoconjugates, which play crucial roles in various biological processes, and aberrant sialylation is closely associated with many diseases, particularly cancers. As SAs are overexpressed in tumor-associated glycoproteins, the recognition and specific binding of SA are crucial for monitoring, analyzing and controlling cancer cells, which would have a considerable impact on diagnostic and therapeutic application. However, both effective and selective recognition of SA on the cancer cell surface remains challenging. In recent years, SA-targeted biointerface materials have attracted great attention in various bio-applications, including cancer detection and imaging, drug delivery for cancer therapy and sialylated glycopeptide separation or enrichment. This review provides an overview of recent advances in SA-targeted biointerface materials and related bio-applications.
机译：唾液酸（SAs）通常被发现是附着在细胞表面糖缀合物上的末端单糖，在各种生物学过程中都起着至关重要的作用，异常的唾液酸化与许多疾病（尤其是癌症）密切相关。由于SA在肿瘤相关糖蛋白中过表达，因此SA的识别和特异性结合对于监测，分析和控制癌细胞至关重要，这将对诊断和治疗应用产生重大影响。然而，在癌细胞表面上对SA的有效和选择性识别仍然具有挑战性。近年来，以SA为靶标的生物界面材料在各种生物应用中引起了极大的关注，包括癌症检测和成像，用于癌症治疗的药物输送以及唾液酸化糖肽的分离或富集。这篇综述概述了以SA为靶标的生物界面材料和相关生物应用的最新进展。

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