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Poly(Lactic- co -Glycolic Acid): Applications and Future Prospects for Periodontal Tissue Regeneration

机译：聚乳酸-乙醇酸：牙周组织再生的应用及未来前景

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Periodontal tissue regeneration is the ultimate goal of the treatment for periodontitis-affected teeth. The success of regenerative modalities relies heavily on the utilization of appropriate biomaterials with specific properties. Poly (lactic- co -glycolic acid) (PLGA), a synthetic aliphatic polyester, has been actively investigated for periodontal therapy due to its favorable mechanical properties, tunable degradation rates, and high biocompatibility. Despite the attractive characteristics, certain constraints associated with PLGA, in terms of its hydrophobicity and limited bioactivity, have led to the introduction of modification strategies that aimed to improve the biological performance of the polymer. Here, we summarize the features of the polymer and update views on progress of its applications as barrier membranes, bone grafts, and drug delivery carriers, which indicate that PLGA can be a good candidate material in the field of periodontal regenerative medicine.
机译：牙周组织再生是治疗牙周炎的牙齿的最终目标。再生方式的成功很大程度上取决于对具有特定特性的适当生物材料的利用。聚（乳酸-共-乙醇酸）（PLGA）是一种合成的脂肪族聚酯，由于其良好的机械性能，可调节的降解速率和高生物相容性，已被积极地研究用于牙周治疗。尽管具有吸引人的特性，但就其疏水性和有限的生物活性而言，与PLGA相关的某些限制因素导致引入了旨在改善聚合物生物学性能的修饰策略。在这里，我们总结了聚合物的特性，并更新了其作为屏障膜，骨移植物和药物输送载体的应用进展的观点，这表明PLGA可以成为牙周再生医学领域的良好候选材料。

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