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首页> 外文期刊>Polymers >Phase Transformation of Adefovir Dipivoxil/Succinic Acid Cocrystals Regulated by Polymeric Additives
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Phase Transformation of Adefovir Dipivoxil/Succinic Acid Cocrystals Regulated by Polymeric Additives

机译：聚合添加剂调节的阿德福韦酯/丁二酸/琥珀酸共晶体的相变

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The polymorphic phase transformation in the cocrystallization of adefovir dipivoxil (AD) and succinic acid (SUC) was investigated. Inspired by biological and biomimetic crystallization, polymeric additives were utilized to control the phase transformation. With addition of poly(acrylic acid), the metastable phase newly identified through the analysis of X-ray diffraction was clearly isolated from the previously reported stable form. Without additives, mixed phases were obtained even at the early stage of cocrystallization. Also, infrared spectroscopy analysis verified the alteration of the hydrogen bonding that was mainly responsible for the cocrystal formation between AD and SUC. The hydrogen bonding in the metastable phase was relatively stronger than that in the stable form, which indicated the locally strong AD/SUC coupling in the initial stage of cocrystallization followed by the overall stabilization during the phase transformation. The stronger hydrogen bonding could be responsible for the faster nucleation of the initially observed metastable phase. The present study demonstrated that the polymeric additives could function as effective regulators for the polymorph-selective cocrystallization.
机译：研究了阿德福韦酯（AD）和琥珀酸（SUC）共结晶中的多晶相转变。受生物和仿生结晶的启发，聚合物添加剂可用于控制相变。通过添加聚丙烯酸，通过X射线衍射分析新鉴定的亚稳相与先前报道的稳定形式明显分离。在没有添加剂的情况下，即使在共结晶的早期也获得了混合相。另外，红外光谱分析证实了氢键的改变，该氢键的改变主要是造成AD和SUC之间共晶形成的原因。亚稳定相中的氢键相对比稳定形式中的氢键相对更强，这表明在共结晶的初始阶段局部强的AD / SUC偶联，随后在相变过程中总体稳定。较强的氢键作用可能是导致最初观察到的亚稳相更快成核的原因。本研究表明，聚合物添加剂可作为多晶型选择性共结晶的有效调节剂。

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