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首页> 外文期刊>Polymers >Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy
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Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

机译：PVA /透明质酸冰晶石对银屑病的毒性，生物相容性，pH响应性和甲氨蝶呤释放

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Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical–chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by “in vivo” tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2–7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.
机译：研究了载有甲氨蝶呤的聚乙烯醇/透明质酸冰冻凝胶。通过FT-IR光谱，扫描电子显微镜，差示扫描量热法和动态机械热分析对冰晶进行了物理化学表征。急性毒性和血液学参数通过“体内”测试确定。生物相容性测试证明，所得冰凝胶显示出明显降低的毒性并且具有生物相容性。在2-7.4的pH区间内研究了聚乙烯醇/透明质酸（PVA / HA）凝胶的溶胀行为和甲氨蝶呤释放的pH反应性。在治疗牛皮癣疾病中受影响的皮肤所特有的pH 5.5下，发现性能发生了显着变化。

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