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首页> 外文期刊>Polymers >Enhancement of Wound Healing in Normal and Diabetic Mice by Topical Application of Amorphous Polyphosphate. Superior Effect of a Host–Guest Composite Material Composed of Collagen (Host) and Polyphosphate (Guest)
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Enhancement of Wound Healing in Normal and Diabetic Mice by Topical Application of Amorphous Polyphosphate. Superior Effect of a Host–Guest Composite Material Composed of Collagen (Host) and Polyphosphate (Guest)

机译：通过局部应用无定形多磷酸盐增强正常和糖尿病小鼠的伤口愈合。胶原蛋白（主体）和多磷酸盐（主体）组成的主体-客体复合材料的优异效果

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The effect of polyphosphate (polyP) microparticles on wound healing was tested both in vitro and in a mice model in vivo. Two approaches were used: pure salts of polyphosphate, fabricated as amorphous microparticles (MPs, consisting of calcium and magnesium salts of polyP, “Ca–polyp-MPs” and “Mg–polyp-MPs”), and host–guest composite particles, prepared from amorphous collagen (host) and polyphosphate (guest), termed “col/polyp-MPs”. Animal experiments with polyP on healing of excisional wounds were performed using both normal mice and diabetic mice. After a healing period of 7 days “Ca–polyp-MP” significantly improved re-epithelialization in normal mice from 31% (control) to 72% (polyP microparticle-treated). Importantly, in diabetic mice, particularly the host–guest particles “col/polyp-MP”, increased the rate of re-epithelialization to ≈40% (control, 23%). In addition, those particles increased the expression of COL-I and COL-III as well as the expression the α-smooth muscle actin and the plasminogen activator inhibitor-1. We propose that “Ca–polyp-MPs”, and particularly the host–guest “col/polyp-MPs” are useful for topical treatment of wounds.
机译：在体外和体内小鼠模型中都测试了多磷酸盐（polyP）微粒对伤口愈合的作用。使用了两种方法：制造为无定形微粒的纯聚磷酸盐（MPs，由polyP的钙和镁盐，“ Ca-polyp-MPs”和“ Mg-polyp-MPs”组成）和主体-客体复合颗粒，由无定形胶原蛋白（宿主）和多磷酸盐（来宾）制成，称为“ col / polyp-MPs”。使用polyP对切除伤口愈合的动物实验是使用正常小鼠和糖尿病小鼠进行的。在7天的愈合期后，“ Ca–polyp-MP”可将正常小鼠的上皮再生从31％（对照）显着提高到72％（经polyP微粒处理）。重要的是，在糖尿病小鼠中，尤其是宿主-客体颗粒“ col / polyp-MP”使上皮再形成率增加到约40％（对照，为23％）。另外，这些颗粒增加了COL-I和COL-III的表达以及α-平滑肌肌动蛋白和纤溶酶原激活物抑制剂-1的表达。我们建议“ Ca-polyp-MPs”，尤其是宿主-来宾“ col / polyp-MPs”可用于局部治疗伤口。

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