Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

Karolina A. Walker; Jean-Fran?ois Stumbé; Rainer Haag

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Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

机译：聚酯基，可生物降解的核-多壳纳米载体，用于疏水药物的运输

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A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments.

机译：合成了一种基于新型超支化聚酯核心构件的水溶性核-多壳（CMS）纳米载体，并表征了该纳米载体的药物转运和降解作用。将疏水性药物地塞米松包封，并通过NMR光谱研究酶介导的生物降解性。新的CMS纳米载体可以转运一分子地塞米松，并在32°C的皮肤温度下五天内降解为生物相容性片段。

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《Polymers》 |2016年第5期|共页
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Karolina A. Walker; Jean-Fran?ois Stumbé; Rainer Haag;
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1. Development of biodegradable hyperbranched core-multishell nanocarriers for efficient topical drug delivery [J] . Du Fang, Hoenzke Stefan, Neumann Falko, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2016,第Null期

机译：可生物降解的超支化核-多壳纳米载体的开发，可有效地局部给药
2. IR780-polymer conjugates for stable near-infrared labeling of biodegradable polyester-based nanocarriers [J] . de Oliveira Maria Alice, Carvalho Machado Marina Guimaraes, Dias Silva Sabrina Emanuelle, European Polymer Journal . 2019,第期

机译：IR780-聚合物缀合物，用于稳定的可生物降解聚酯基纳米载体的近红外标记
3. Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy [J] . Yamamoto K., Klossek A., Flesch R., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2016,第Null期

机译：核心-多壳纳米载体：通过软X射线光谱显微镜探测的地塞米松的转运和释放
4. Encapsulation of a hydrophobic drug in polyphosphate-based nanocarriers [C] . Stephanie Vanslambrouck, Benoit Clement, Raphaeel Riva, World biomaterials congress . 2016

机译：疏水性药物在多磷酸盐基纳米载体中的包封
5. Synthesis, characterization, and property study of hydrophilic-hydrophobic biodegradable hydrogels as a controlled drug delivery system. [D] . Zhang, Yeli. 2000

机译：亲水-疏水可生物降解水凝胶的合成，表征和性能研究，作为可控药物递送系统。
6. Polyester-Based Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs [O] . Karolina A. Walker, Jean-François Stumbé, Rainer Haag 2016

机译：聚酯基可生物降解的核-多壳纳米载体用于疏水药物的运输
7. Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs [O] . Karolina A. Walker, Jean-François Stumbé, Rainer Haag 2016

机译：聚酯基，可生物降解的核 - 多壳纳米载体，用于运输疏水性药物
8. Synthesis of Biodegradable Polymers and Development of Biodegradable Hollow Fibres for the Controlled Release of Drugs [R] . Eenink, M. J. D. 1987

机译：可生物降解聚合物的合成及可控制释放药物的可生物降解中空纤维的开发

Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

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