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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy
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The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy

机译：孕妇一氧化氮合酶基因的VNTR多态性与血压

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ObjectiveExamine the association of the 4a/4b polymorphism of endothelial nitric oxide synthase (eNOS) with blood pressure in women at late pregnancy.Materials and methodsBlood pressure before pregnancy and at the end of gestation (37–40-week term) was measured in 588 women of the Russian ancestry. The women were divided into groups according to the body mass index and the presence of preeclampsia at late pregnancy. The 4a/4b polymorphism of theeNOS gene was genotyped using PCR with subsequent screening of amplified fragment length polymorphisms.ResultsThe 4a4aeNOSgenotype was associated with higher levels of diastolic blood pressure in pregnant women and with more pronounced dynamics of the diastolic and mean arterial pressure in the development of pregnancy (p?=?0.02–0.03). Pregnant women with the 4a4a genotype and increased body mass index had higher systolic, diastolic, and mean arterial pressure (p?=?0.001–0.009). In pregnant women with preeclampsia, the 4a4a genotype was associated with higher level of diastolic blood pressure at the end of pregnancy (p?=?0.04), whereas in the women without preeclampsia this genotype was associated with more pronounced changes of blood pressure at pregnancy (p?=?0.02).ConclusionThe results of our study suggest that the genotype 4a4a of theeNOSgene is associated with higher levels of blood pressure in women at the end of pregnancy.
机译：目的检查妊娠晚期妇女内皮型一氧化氮合酶（eNOS）4a / 4b多态性与血压的关系。材料和方法在588年测定了妊娠前和妊娠末期（37-40周龄）的血压。俄罗斯血统的女性。根据体重指数和妊娠后期先兆子痫的存在将妇女分为几组。通过PCR对eNOS基因的4a / 4b多态性进行基因分型，然后筛选扩增的片段长度多态性。结果4a4aeNOS基因型与孕妇的舒张压水平较高以及发育过程中舒张压和平均动脉压的动态变化有关。 （p？=？0.02–0.03）。具有4a4a基因型和体重指数增加的孕妇，其收缩压，舒张压和平均动脉压较高（p？=？0.001-0.009）。在子痫前期的孕妇中，4a4a基因型与妊娠末期舒张压升高相关（p？=？0.04），而在没有子痫前期的孕妇中，该基因型与妊娠期血压变化更明显有关。 （p？=？0.02）。结论我们的研究结果表明，eNOS基因的4a4a基因型与妊娠末期妇女的血压升高有关。

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