...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >GnRH Antagonist/Letrozole Versus Microdose GnRH Agonist Flare Protocol in Poor Responders Undergoing In Vitro Fertilization
【24h】

GnRH Antagonist/Letrozole Versus Microdose GnRH Agonist Flare Protocol in Poor Responders Undergoing In Vitro Fertilization

机译：GnRH拮抗剂/来曲唑与微剂量GnRH激动剂在受精中的反应体外

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Objective To evaluate and compare the efficacy of microdose gonadotropin-releasing hormone (GnRH) agonist flare (MF) and GnRH antagonist/letrozole protocols in poor responders undergoing in vitro fertilization. Materials and Methods A total of 94 poorly responding patients were randomized in an ovarian stimulation protocol with a MF, or a letrozole and high dose follicle-stimulating hormone/human menopausal gonadotropin and flexible GnRH antagonist protocol. Results There was no significant difference in mean age, body mass index, basal serum follicle stimulating hormone and estradiol levels, duration of infertility, distribution of etiology of infertility, and the number of previously failed in vitro fertilization cycles. The days of stimulation, mean gonadotropin dose, the number of mature follicles, and oocytes retrieved and metaphase II oocytes retrieved, serum estradiol level on the day of human chorionic gonadotropin administration, and the percentage of top and good quality embryos were significantly higher in the MF group. The endometrial thickness, fertilization rate, and the number of embryos transferred were similar in both groups. The implantation and clinical pregnancy rates were higher in the MF group and the total cancellation rate was higher in the GnRH antagonist/letrozole group, but these findings were not statistically significant. Conclusion The addition of letrozole to the GnRH antagonist for poor responders does not improve the outcome of assisted reproductive technology cycles. The MF protocol remains the most appropriate protocol in poor responders.
机译：摘要目的评估和比较微剂量促性腺激素释放激素（GnRH）激动剂耀斑（MF）和GnRH拮抗剂/来曲唑方案在体外受精不良反应者中的疗效。材料和方法总共94例反应不佳的患者被随机分为卵巢刺激方案，MF，来曲唑和高剂量促卵泡激素/人类更年期促性腺激素和灵活的GnRH拮抗剂方案。结果：平均年龄，体重指数，基础血清卵泡刺激素和雌二醇水平，不孕持续时间，不孕病因分布以及先前失败的体外受精次数均无显着差异。在给予绒毛膜促性腺激素的当天，刺激的天数，促性腺激素的平均剂量，回收的成熟卵泡的数量，卵母细胞的数目以及回收的中期II卵母细胞的水平，血清雌二醇水平以及优质胚胎的百分比显着增加。 MF集团。两组的子宫内膜厚度，受精率和转移的胚数相似。 MF组的着床率和临床妊娠率更高，GnRH拮抗剂/来曲唑组的总消除率更高，但这些发现没有统计学意义。结论对于反应较差的人，在GnRH拮抗剂中添加来曲唑不能改善辅助生殖技术周期的结果。 MF协议仍然是较差响应者中最合适的协议。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号