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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Deleterious Effects of Arsenic, Benomyl and Carbendazim on Human Endometrial Cell Proliferation In Vitro
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Deleterious Effects of Arsenic, Benomyl and Carbendazim on Human Endometrial Cell Proliferation In Vitro

机译：砷，苯菌灵和多菌灵对人子宫内膜细胞增殖的有害作用体外

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Summary Objective We aimed to investigate the effects of arsenic (As), benomyl (Ben), and carbendazim (Carb) on endometrial cells. Materials and Methods Human endometrial cells were obtained during diagnostic curettage. All cultured endometrial cells were divided into four groups: (1) 0 M (controls), (2) 10 ?6 M, (3) 10 ?5 M, (4) 10 ?4 M for As, Ben and Carb. After 24 and 48 hours in culture, endometrial cell proliferations were assessed by diphenyltetrazolium bromide assay. The influences of different concentrations of As, Ben and Carb upon the endometrium were compared. Results During the first 24 hours, As, Ben and Carb appeared to have insignificant influences upon endometrial growth. After 48 hours in culture, all three agents significantly inhibited endometrial growth. In As groups, cell absorption after 48 hours culture were 100% (group 1), 82.1% (group 2), 43.6% (group 3) and 35.3% (group 4). In Ben groups, cell absorption was 100% (1), 75.9% (2), 66.4% (3) and 49. 6% (4). In the Carb groups, cell absorption was 100% (1), 70.4% (2), 73.0% (3) and 76.7% (4). Conclusion The agents As, Ben and Carb appear to have inhibitory effects upon endometrial cells after 48 hours in culture.
机译：摘要目的我们旨在研究砷（As），苯菌灵（Ben）和多菌灵（Carb）对子宫内膜细胞的影响。材料和方法在诊断刮宫过程中获得了人子宫内膜细胞。将所有培养的子宫内膜细胞分为四组：（1）0 M（对照），（2）10？6 M，（3）10？5 M，（4）10？4 M的As，Ben和Carb。培养24和48小时后，通过溴二苯四唑测定评估子宫内膜细胞的增殖。比较了不同浓度的As，Ben和Carb对子宫内膜的影响。结果在最初的24小时内，As，Ben和Carb对子宫内膜的生长影响不大。培养48小时后，所有三种药物均显着抑制子宫内膜生长。在As组中，培养48小时后的细胞吸收为100％（组1），82.1％（组2），43.6％（组3）和35.3％（组4）。在Ben组中，细胞吸收率为100％（1），75.9％（2），66.4％（3）和49.6％（4）。在Carb组中，细胞吸收率为100％（1），70.4％（2），73.0％（3）和76.7％（4）。结论培养48小时后，As，Ben和Carb剂似乎对子宫内膜细胞具有抑制作用。

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