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首页> 外文期刊>Polymers >Thermogel-Coated Poly(ε-Caprolactone) Composite Scaffold for Enhanced Cartilage Tissue Engineering
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Thermogel-Coated Poly(ε-Caprolactone) Composite Scaffold for Enhanced Cartilage Tissue Engineering

机译：用于增强软骨组织工程的热凝胶涂层聚（ε-己内酯）复合支架

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摘要

A three-dimensional (3D) composite scaffold was prepared for enhanced cartilage tissue engineering, which was composed of a poly(ε-caprolactone) (PCL) backbone network and a poly(lactide- co -glycolide)- block -poly(ethylene glycol)- block -poly(lactide- co -glycolide) (PLGA–PEG–PLGA) thermogel surface. The composite scaffold not only possessed adequate mechanical strength similar to native osteochondral tissue as a benefit of the PCL backbone, but also maintained cell-friendly microenvironment of the hydrogel. The PCL network with homogeneously-controlled pore size and total pore interconnectivity was fabricated by fused deposition modeling (FDM), and was impregnated into the PLGA–PEG–PLGA solution at low temperature (e.g., 4 °C). The PCL/Gel composite scaffold was obtained after gelation induced by incubation at body temperature ( i.e. , 37 °C). The composite scaffold showed a greater number of cell retention and proliferation in comparison to the PCL platform. In addition, the composite scaffold promoted the encapsulated mesenchymal stromal cells (MSCs) to differentiate chondrogenically with a greater amount of cartilage-specific matrix production compared to the PCL scaffold or thermogel. Therefore, the 3D PCL/Gel composite scaffold may exhibit great potential for in vivo cartilage regeneration.
机译：制备了三维（3D）复合支架，用于增强软骨组织工程，该支架由聚（ε-己内酯）（PCL）主链网络和聚（丙交酯-共-乙交酯）-嵌段-聚（乙二醇）组成）-嵌段聚丙交酯-乙交酯（PLGA–PEG–PLGA）热凝胶表面。复合支架不仅具有与天然骨软骨组织相似的足够的机械强度，这是PCL主链的优势，而且还保持了水凝胶对细胞友好的微环境。 PCL网络具有均匀受控的孔径和总的孔互连性，是通过熔融沉积建模（FDM）制成的，并在低温（例如4°C）下浸渍到PLGA-PEG-PLGA溶液中。在体温（即37℃）下温育诱导凝胶化后，获得PCL / Gel复合支架。与PCL平台相比，复合支架显示出更多的细胞保留和增殖。此外，与PCL支架或热凝胶相比，复合支架促进封装的间充质基质细胞（MSC）分化成软骨，并产生更多的软骨特异性基质。因此，3D PCL / Gel复合支架可能展现出体内软骨再生的巨大潜力。

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