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首页> 外文期刊>Pathology and Laboratory Medicine International >Abnormal hemoglobin genotypes and ABO and rhesus blood groups associated with HIV infection among HIV-exposed infants in North Western Nigeria
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Abnormal hemoglobin genotypes and ABO and rhesus blood groups associated with HIV infection among HIV-exposed infants in North Western Nigeria

机译：尼日利亚西北部暴露于HIV的婴儿中与HIV感染相关的异常血红蛋白基因型，ABO和恒河猴血型

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Background: Hemoglobin genotypes and blood groups have been known to be associated with diseases, but the relationship with human immunodeficiency virus (HIV) infection among Nigerian infants is not well known.Objective: This study aims to determine the association between hemoglobin genotypes and blood groups with HIV infection among HIV-exposed Nigerian infants.Methods: This cross-sectional study examined 312 HIV-exposed infants (aged 8–16 months) in Sokoto State, Nigeria. HIV screening was performed using the HIV DNA polymerase chain reaction technique on dried blood spots. Hemoglobin electrophoresis and ABO and Rhesus (Rh) blood groups were carried out using standard techniques.Results: This study found 20.5% HIV-1 seropositivity among the infants, with 20.9% of males and 20.1% of females positive for HIV-1. Babies' sex and HIV seropositivity was not significant (χ2=0.27, df=1, P=0.869). The blood group distribution was O (43.3%), A (36.8%), B (15.7%), AB (4.2%), RhD+ (95.6%), and RhD– (4.4%). The combined ABO and Rh blood groups among the study population were O+ (40.1%), A+ (36.2%), B+ (15.1%), AB+ (4.2%), O– (3.2%), A– (0.6%), and B– (0.6%). No AB– baby was found. The association between blood groups and HIV seropositivity was not significant (Fisher’s exact test =9.140; P=0.169); however, group AB+ showed the highest probable association with HIV seropositivity (46.2%), followed by A+ (23.9%). The prevalence of hemoglobin genotypes was AA (71.5%), AS (25.3%), AC (2.2%), and SC (1.0%). Hemoglobin SS and other hemoglobin variants were not found. A significant association (χ2=8.432, df=3, P=0.034) was observed between SC and HIV-1 infection, but not with ABO and Rh blood groups.Conclusion: Hemoglobin variant SC showed a significant association with HIV-1 infection, but not with ABO and Rh blood groups. Further studies are recommended to confirm this finding.
机译：背景：血红蛋白基因型和血型与疾病有关，但尼日利亚婴儿与人类免疫缺陷病毒（HIV）感染的关系尚不清楚。目的：本研究旨在确定血红蛋白基因型与血型之间的关系方法：这项横断面研究调查了尼日利亚索科托州的312名HIV暴露婴儿（8-16个月大）。使用HIV DNA聚合酶链反应技术对干血斑进行HIV筛查。结果：本研究发现婴儿中HIV-1血清阳性率为20.5％，其中男性为20.9％，女性为20.1％，HIV-1阳性。婴儿的性别和HIV血清阳性率不显着（χ2= 0.27，df = 1，P = 0.869）。血型分布为O（43.3％），A（36.8％），B（15.7％），AB（4.2％），RhD +（95.6％）和RhD–（4.4％）。在研究人群中，ABO和Rh血型合计为O +（40.1％），A +（36.2％），B +（15.1％），AB +（4.2％），O–（3.2％），A–（0.6％），和B–（0.6％）。找不到AB–婴儿。血型与HIV血清阳性之间的关联并不显着（Fisher的精确检验= 9.140; P = 0.169）;但是，AB +组与HIV血清阳性的相关性最高（46.2％），其次是A +（23.9％）。血红蛋白基因型的患病率为AA（71.5％），AS（25.3％），AC（2.2％）和SC（1.0％）。找不到血红蛋白SS和其他血红蛋白变体。在SC和HIV-1感染之间观察到显着相关性（χ2= 8.432，df = 3，P = 0.034），但与ABO和Rh血型没有相关性。结论：血红蛋白变异体SC显示与HIV-1感染显着相关，但不适用于ABO和Rh血型。建议进一步研究以确认这一发现。

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