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首页> 外文期刊>The American journal of pathology. >Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses
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Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses

机译：季节性和大流行的人类流感病毒比禽流感病毒更容易附着在人类上呼吸道上皮上

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摘要

Influenza viruses vary markedly in their efficiency of human-to-human transmission. This variation has been speculated to be determined in part by the tropism of influenza virus for the human upper respiratory tract. To study this tropism, we determined the pattern of virus attachment by virus histochemistry of three human and three avian influenza viruses in human nasal septum, conchae, nasopharynx, paranasal sinuses, and larynx. We found that the human influenza viruses--two seasonal influenza viruses and pandemic H1N1 virus--attached abundantly to ciliated epithelial cells and goblet cells throughout the upper respiratory tract. In contrast, the avian influenza viruses, including the highly pathogenic H5N1 virus, attached only rarely to epithelial cells or goblet cells. Both human and avian viruses attached occasionally to cells of the submucosal glands. The pattern of virus attachment was similar among the different sites of the human upper respiratory tract for each virus tested. We conclude that influenza viruses that are transmitted efficiently among humans attach abundantly to human upper respiratory tract, whereas inefficiently transmitted influenza viruses attach rarely. These results suggest that the ability of an influenza virus to attach to human upper respiratory tract is a critical factor for efficient transmission in the human population.
机译：流感病毒在人与人之间传播的效率上差异很大。据推测，这种变化部分取决于人类上呼吸道的流感病毒的向性。为了研究这种向性，我们通过病毒组织化学确定了三种人类和三种禽流感病毒在人鼻中隔，外耳，鼻咽，鼻旁窦和喉中的病毒附着模式。我们发现人类流感病毒-两种季节性流感病毒和大流行H1N1病毒-大量附着于整个上呼吸道的纤毛上皮细胞和杯状细胞。相反，包括高致病性H5N1病毒在内的禽流感病毒很少附着在上皮细胞或杯状细胞上。人和禽类病毒偶尔都附着在粘膜下腺细胞上。对于每种测试的病毒，在人类上呼吸道的不同部位之间的病毒附着模式相似。我们得出的结论是，在人与人之间有效传播的流感病毒会大量附着在人的上呼吸道上，而无法有效传播的流感病毒很少会附着。这些结果表明，流感病毒附着于人上呼吸道的能力是在人群中有效传播的关键因素。

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