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首页> 外文期刊>The bone & joint journal. >The impact of including corticosteroid in a periarticular injection for pain control after total knee arthroplasty
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The impact of including corticosteroid in a periarticular injection for pain control after total knee arthroplasty

机译：全膝关节置换术后在关节周围注射中包括皮质类固醇激素对控制疼痛的影响

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There is conflicting evidence about the benefitof using corticosteroid in periarticular injections for pain reliefafter total knee arthroplasty (TKA). We carried out a double-blinded,randomised controlled trial to assess the efficacy of using corticosteroidin a periarticular injection to control pain after TKA. A total of 77 patients, 67 women and ten men, with a mean ageof 74 years (47 to 88) who were about to undergo unilateral TKAwere randomly assigned to have a periarticular injection with orwithout corticosteroid. The primary outcome was post-operative painat rest during the first 24 hours after surgery, measured everytwo hours using a visual analogue pain scale score. The cumulativepain score was quantified using the area under the curve. The corticosteroid group had a significantly lower cumulativepain score than the no-corticosteroid group during the first 24hours after surgery (mean area under the curve 139, 0 to 560, and264, 0 to 1460; p = 0.024). The rate of complications, includingsurgical site infection, was not significantly different betweenthe two groups up to one year post-operatively. The addition of corticosteroid to the periarticular injectionsignificantly decreased early post-operative pain. Further studiesare needed to confirm the safety of corticosteroid in periarticularinjection.Take home message: The use of corticosteroid inperiarticular injection offered better pain relief during the initial24 hours after TKA.Cite this article: Bone Joint J 2016;98-B:194–200.
机译：关于在全膝关节置换术（TKA）后关节周围注射使用皮质类固醇激素来缓解疼痛的益处，存在相互矛盾的证据。我们进行了一项双盲，随机对照试验，以评估在关节周围注射使用皮质类固醇激素控制TKA后疼痛的疗效。随机分配平均年龄为74岁（47至88岁）的77例患者（平均年龄为47岁至88岁），这些患者将接受单侧TKA关节腔注射或不使用皮质类固醇。主要结局是术后头24小时的手术后休息时的疼痛，使用视觉模拟疼痛量表评分每两小时测量一次。使用曲线下的面积量化疼痛累积分数。皮质类固醇组在术后头24小时的累积疼痛评分明显低于非皮质类固醇组（曲线下的平均面积139，0至560和264，0至1460; p = 0.024）。两组之间的并发症发生率（包括手术部位感染）在术后一年以内没有显着差异。关节周围注射皮质类固醇激素可显着减轻术后早期疼痛。需要进一步的研究，以确认皮质类固醇在关节周围注射中的安全性。温馨提示：在TKA术后最初的24小时内，使用皮质类固醇关节腔内注射可更好地缓解疼痛。引用本文：Bone Joint J 2016; 98-B：194–200。

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