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首页> 外文期刊>The British journal of psychiatry : >Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder
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Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder

机译：单胺氧化酶A基因启动子甲基化和转录下调与反社会人格障碍的犯罪人口

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Background Antisocial personality disorder (ASPD) is characterised by elevated impulsive aggression and increased risk for criminal behaviour and incarceration. Deficient activity of the monoamine oxidase A ( MAOA ) gene is suggested to contribute to serotonergic system dysregulation strongly associated with impulsive aggression and antisocial criminality. Aims To elucidate the role of epigenetic processes in altered MAOA expression and serotonin regulation in a population of incarcerated offenders with ASPD compared with a healthy non-incarcerated control population. Method Participants were 86 incarcerated participants with ASPD and 73 healthy controls. MAOA promoter methylation was compared between case and control groups. We explored the functional impact of MAOA promoter methylation on gene expression in vitro and blood 5-HT levels in a subset of the case group. Results Results suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro , and regression analysis with whole-blood serotonin levels in offenders with ASPD. Conclusions These results are consistent with prior literature suggesting MAOA and serotonergic dysregulation in antisocial populations. Our results offer the first evidence suggesting epigenetic mechanisms may contribute to MAOA dysregulation in antisocial offenders.
机译：背景技术反社会人格障碍（ASPD）的特征是冲动攻击性增强，犯罪行为和监禁风险增加。单胺氧化酶A（MAOA）基因活性不足，被认为是与冲动性攻击和反社会犯罪密切相关的血清素系统失调的原因。目的为了阐明表观遗传过程在患有ASPD的被监禁罪犯人群中与健康非被监禁的对照人群相比，在改变MAOA表达和5-羟色胺调节中的作用。方法参与者为86名ASPD入狱参与者和73名健康对照者。比较病例组和对照组的MAOA启动子甲基化。我们探讨了病例组的一个子集中，MAOA启动子甲基化对基因表达和血液中5-HT水平的功能影响。结果结果表明，MAOA启动子的高甲基化与ASPD相关，并且可能导致MAOA基因表达的下调，如体外功能测定和对ASPD罪犯的全血5-羟色胺水平进行回归分析所表明的。结论这些结果与先前的文献表明在反社会人群中存在MAOA和血清素能失调相一致。我们的结果提供了第一个证据，表明表观遗传机制可能导致反社会罪犯的MAOA失调。

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