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首页> 外文期刊>The British journal of psychiatry : >Grey matter abnormalities in obsessive—compulsive disorder
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Grey matter abnormalities in obsessive—compulsive disorder

机译：强迫症中的灰质异常

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Background Although a number of functional imaging studies are in agreement in suggesting orbitofrontal and subcortical hyperfunction in the pathophysiology of obsessivea€”compulsive disorder (OCD), the structural findings have been contradictory. Aims To investigate grey matter abnormalities in patients with OCD by employing a novel voxel-based analysis of magnetic resonance images. Method Statistical parametric mapping was utilised to compare segmented grey matter images from 25 patients with OCD with those from 25 matched controls. Results Increased regional grey matter density was found in multiple cortical areas, including the left orbitofrontal cortex, and in subcortical areas, including the thalamus. On the other hand, regions of reduction were confined to posterior parts of the brain, such as the left cuneus and the left cerebellum. Conclusions Increased grey matter density of frontala€”subcortical circuits, consonant with the hypermetabolic findings from functional imaging studies, seems to exist in patients with OCD, and cerebellar dysfunction may be involved in the pathophysiology of OCD.
机译：背景技术尽管许多功能成像研究在强迫症（OCD）的病理生理学中提示眶额和皮层下功能亢进方面是一致的，但结构发现是矛盾的。目的通过采用基于体素的磁共振成像分析来研究强迫症患者的灰质异常。方法利用统计参数映射将来自25位OCD患者的分段灰质图像与来自25位匹配对照的图像进行比较。结果在包括左眶额叶皮层在内的多个皮质区域和包括丘脑在内的皮质下区域发现了区域灰质密度的增加。另一方面，减少的区域仅限于大脑的后部，例如左楔骨和左小脑。结论OCD患者似乎存在额叶皮层下回路灰质密度增加，这与功能成像研究的代谢异常有关，小脑功能障碍可能与OCD的病理生理有关。

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