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首页> 外文期刊>The British journal of psychiatry : >First-episode major depression in adolescents
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First-episode major depression in adolescents

机译：青少年第一集严重抑郁症

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Background There is little information on whether patterns of steroids precede and are associated with depressive onset. Aims To establish whether there is an association between salivary cortisol and or dihydroepiandrosterone (DHEA) levels and depression independent of psychosocial risk. Method Two subgroups of adolescents in the community at high ( n =181) and low ( n =65) risk for psychopathology were interviewed for recent psychiatric disorder at entry and again at 12 months. Salivary samples (08.00 and 20.00 h) for hormone estimations and self-reports on current mood and cognitive style were obtained at both assessments. Results Neither hormone was associated with risk status, current mood or cognitive style at entry. Of 31 onsets of major depression that occurred over the next 12 months, 30 came from the high-risk group but were not associated with any particular pattern of risk. Increased negative mood and feelings and DHEA (08.00 h) hypersecretion at entry were associated with subsequent major depression. Conclusions Both negative mood and feelings and alterations in adrenal steroid function precede the onset of first-episode major depression in adolescents. Variation in levels of hormones may arise from more distal origins than recent life events and current ongoing difficulties.
机译：背景很少有关于类固醇激素模式是否先发并与抑郁发作有关的信息。目的确定唾液皮质醇和/或二氢表雄酮（DHEA）水平与抑郁之间是否存在关联，而与心理社会风险无关。方法在入院时和入院后12个月，对社区中精神病学高风险（n = 181）和低风险（n = 65）的两个青少年亚组进行了近期访谈。在这两次评估中均获得了唾液样本（08.00和20.00 h），用于激素估计以及关于当前情绪和认知方式的自我报告。结果两种激素均与进入时的危险状态，当前的情绪或认知方式无关。在接下来的12个月中发生的31例重大抑郁症发作中，有30例来自高危人群，但与任何特定风险模式均无关。进入时负面情绪和感觉的增加以及DHEA（08.00 h）的过度分泌与随后的严重抑郁症相关。结论不良情绪和感觉以及肾上腺类固醇功能的改变均在青少年首次发作严重抑郁之前发生。与最近的生活事件和当前持续的困难相比，更多的远端起源可能导致激素水平的变化。

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